SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 PRO C 271
GLU C 157
GLN C 270
VAL C 303
 PO4  C 401 ( 4.6A)
None
None
None
 1.10A 1l2iB-5dwzC:
undetectable		 1l2iB-5dwzC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 PRO C  14
GLY C 298
GLY C  45
SER C 304
HIS C 269
 None
None
None
None
PO4  C 401 (-3.9A)
 1.21A 1wg8B-5dwzC:
undetectable		 1wg8B-5dwzC:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 11 LEU C 193
ALA C 252
VAL C 325
ILE C 283
VAL C 339
 None
 1.06A 2nnpB-5dwzC:
undetectable		 2nnpB-5dwzC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 GLN C 289
PHE C 266
PHE C 268
GLY C 282
 None
 1.44A 2qmzA-5dwzC:
undetectable
2qmzB-5dwzC:
undetectable		 2qmzA-5dwzC:
22.77
2qmzB-5dwzC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 9 TRP C 340
PHE C 132
SER C  83
ALA C 139
LEU C 136
 None
 1.30A 2wscA-5dwzC:
undetectable		 2wscA-5dwzC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 9 TRP C 340
PHE C 132
SER C  83
ALA C 139
LEU C 136
 None
 1.30A 2wseA-5dwzC:
undetectable		 2wseA-5dwzC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 9 TRP C 340
PHE C 132
SER C  83
ALA C 139
LEU C 136
 None
 1.30A 2wsfA-5dwzC:
undetectable		 2wsfA-5dwzC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		3 / 3 ARG C  16
ASP C 175
ASP C  48
 None
 0.89A 3jb3A-5dwzC:
undetectable		 3jb3A-5dwzC:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 6 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.23A 3ko0B-5dwzC:
undetectable		 3ko0B-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 11 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.17A 3ko0C-5dwzC:
undetectable
3ko0D-5dwzC:
undetectable
3ko0E-5dwzC:
undetectable
3ko0F-5dwzC:
undetectable		 3ko0C-5dwzC:
14.11
3ko0D-5dwzC:
14.11
3ko0E-5dwzC:
14.11
3ko0F-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.22A 3ko0K-5dwzC:
undetectable
3ko0L-5dwzC:
undetectable
3ko0S-5dwzC:
undetectable
3ko0T-5dwzC:
undetectable		 3ko0K-5dwzC:
14.11
3ko0L-5dwzC:
14.11
3ko0S-5dwzC:
14.11
3ko0T-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.23A 3ko0K-5dwzC:
undetectable
3ko0L-5dwzC:
undetectable
3ko0M-5dwzC:
undetectable
3ko0N-5dwzC:
undetectable		 3ko0K-5dwzC:
14.11
3ko0L-5dwzC:
14.11
3ko0M-5dwzC:
14.11
3ko0N-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 11 LEU C 133
SER C 131
PHE C 132
ILE C 305
PHE C 173
 None
None
None
None
PO4  C 401 (-4.6A)
 1.10A 3ko0K-5dwzC:
undetectable
3ko0L-5dwzC:
undetectable
3ko0M-5dwzC:
undetectable
3ko0N-5dwzC:
undetectable		 3ko0K-5dwzC:
14.11
3ko0L-5dwzC:
14.11
3ko0M-5dwzC:
14.11
3ko0N-5dwzC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 9 TRP C 340
PHE C 132
SER C  83
ALA C 139
LEU C 136
 None
 1.34A 3lw5A-5dwzC:
undetectable		 3lw5A-5dwzC:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 TYR C 307
ALA C 178
GLY C 176
SER C 304
MET C 300
 None
 1.28A 3pfgA-5dwzC:
undetectable		 3pfgA-5dwzC:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 ARG C 137
ILE C  81
VAL C 151
LEU C 182
 None
 1.01A 4em2A-5dwzC:
undetectable		 4em2A-5dwzC:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		5 / 12 GLY C 116
PRO C  74
LEU C  67
MET C 107
GLU C  64
 None
 1.25A 4x61A-5dwzC:
undetectable		 4x61A-5dwzC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 ARG C 323
GLN C 341
ILE C 263
ASP C 264
 None
 1.30A 4z4hA-5dwzC:
undetectable		 4z4hA-5dwzC:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 8 PHE C 132
SER C  83
LEU C 134
LEU C 133
 None
 1.07A 5dzkF-5dwzC:
undetectable
5dzkT-5dwzC:
undetectable		 5dzkF-5dwzC:
21.01
5dzkT-5dwzC:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 6 PHE C 230
PHE C 240
SER C 228
VAL C 206
 None
 0.71A 5hesA-5dwzC:
undetectable		 5hesA-5dwzC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		3 / 3 LYS C 150
ASP C  78
ARG C 184
 None
 0.63A 5jwaA-5dwzC:
undetectable
5jwaH-5dwzC:
undetectable		 5jwaA-5dwzC:
17.53
5jwaH-5dwzC:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 5 ILE C 159
PHE C  47
SER C 156
ALA C 174
 None
 1.05A 5msdA-5dwzC:
undetectable		 5msdA-5dwzC:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Pseudomonas
aeruginosa) 		4 / 4 PRO C 122
MET C 142
GLY C 146
VAL C 151
 CL  C 409 ( 4.9A)
None
None
None
 1.25A 6ak3A-5dwzC:
undetectable		 6ak3A-5dwzC:
14.50