SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 ASP A 210
THR A 213
GLU A 180
 MG  A 401 (-2.8A)
None
T6P  A 402 (-2.7A)
 0.75A 1pj7A-5dx9A:
undetectable		 1pj7A-5dx9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 6 ASP A  26
THR A 138
GLU A 180
GLU A 131
 T6P  A 402 ( 2.9A)
T6P  A 402 (-3.1A)
T6P  A 402 (-2.7A)
T6P  A 402 (-2.4A)
 1.46A 2dttB-5dx9A:
undetectable
2dttC-5dx9A:
undetectable		 2dttB-5dx9A:
19.30
2dttC-5dx9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 8 SER A 136
VAL A 186
PHE A  90
ASN A 101
 None
 0.98A 2wekA-5dx9A:
3.9		 2wekA-5dx9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 8 SER A 136
VAL A 186
PHE A  90
ASN A 101
 None
 0.98A 2wekB-5dx9A:
4.0		 2wekB-5dx9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 6 LEU A  20
VAL A 202
VAL A 192
PHE A 225
 None
 1.14A 3soaA-5dx9A:
1.9		 3soaA-5dx9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 4 LYS A 134
GLU A 115
ILE A 137
SER A 136
 None
 1.42A 4ac9C-5dx9A:
2.2		 4ac9C-5dx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 4 LYS A 134
GLU A 115
ILE A 137
SER A 136
 None
 1.40A 4acaC-5dx9A:
2.1		 4acaC-5dx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 4 LYS A 134
GLU A 115
ILE A 137
SER A 136
 None
 1.45A 4acbC-5dx9A:
undetectable		 4acbC-5dx9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 GLU A 249
ILE A 100
ALA A 105
 None
 0.64A 4wnwB-5dx9A:
undetectable		 4wnwB-5dx9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 LEU A 157
ASP A 158
TYR A 141
LEU A 179
 BME  A 403 ( 3.5A)
None
BME  A 403 (-3.4A)
BME  A 403 ( 4.3A)
 1.27A 4wozF-5dx9A:
undetectable
4wozH-5dx9A:
undetectable		 4wozF-5dx9A:
22.83
4wozH-5dx9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  62
LEU A  29
PHE A   9
LEU A  52
ILE A  49
 None
 0.98A 4x1fA-5dx9A:
undetectable		 4x1fA-5dx9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  62
LEU A  29
PHE A   9
LEU A  52
ILE A  49
 None
 0.97A 4x1gA-5dx9A:
undetectable		 4x1gA-5dx9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 205
GLY A 267
GLU A 190
PHE A 218
ALA A 282
 None
 0.98A 5igyA-5dx9A:
undetectable		 5igyA-5dx9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 GLU A 116
TYR A 120
ARG A 124
 None
 0.74A 5uunA-5dx9A:
undetectable		 5uunA-5dx9A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 GLU A 116
TYR A 120
ARG A 124
 None
 0.82A 5uunB-5dx9A:
undetectable		 5uunB-5dx9A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.25A 5vooA-5dx9A:
undetectable		 5vooA-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.25A 5vooB-5dx9A:
undetectable		 5vooB-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.23A 5vooC-5dx9A:
undetectable		 5vooC-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.22A 5vooD-5dx9A:
undetectable		 5vooD-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 5 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.22A 5vooE-5dx9A:
undetectable		 5vooE-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		4 / 4 ASP A 214
ASN A  24
ASP A  26
ASN A 178
 T6P  A 402 ( 4.3A)
MG  A 401 ( 2.5A)
T6P  A 402 ( 2.9A)
T6P  A 402 (-3.5A)
 1.24A 5vooF-5dx9A:
1.4		 5vooF-5dx9A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		3 / 3 HIS A 140
ASN A 178
LEU A 179
 T6P  A 402 (-3.7A)
T6P  A 402 (-3.5A)
BME  A 403 ( 4.3A)
 0.90A 6f7lB-5dx9A:
2.6		 6f7lB-5dx9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  21
THR A   6
TYR A  13
ALA A  51
ARG A  44
 None
 1.19A 6ie8A-5dx9A:
undetectable		 6ie8A-5dx9A:
22.58