SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		4 / 7 MET A 195
VAL A 173
ILE A 175
TYR A 204
 None
 1.12A 2yfbA-5dxdA:
undetectable		 2yfbA-5dxdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		4 / 8 TRP A 126
GLU A 146
ILE A 175
TRP A 147
 None
 1.13A 3e7gC-5dxdA:
undetectable
3e7gD-5dxdA:
undetectable		 3e7gC-5dxdA:
20.37
3e7gD-5dxdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		4 / 5 THR A 158
GLY A 156
VAL A 173
PRO A 172
 None
 0.99A 4grkA-5dxdA:
undetectable		 4grkA-5dxdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		4 / 5 GLY A  37
SER A  38
ALA A  39
PHE A  77
 None
 1.01A 4m93B-5dxdA:
undetectable
4m93C-5dxdA:
undetectable		 4m93B-5dxdA:
22.26
4m93C-5dxdA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		4 / 5 ARG A  51
PRO A  63
ILE A  54
ASP A  61
 None
 1.17A 4z4hA-5dxdA:
undetectable		 4z4hA-5dxdA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		3 / 3 GLU A 146
TRP A 153
HIS A 160
 None
 1.10A 5xipA-5dxdA:
undetectable		 5xipA-5dxdA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 165
SER A 211
VAL A 207
VAL A 159
ASP A 143
 None
 1.18A 6bxlB-5dxdA:
undetectable		 6bxlB-5dxdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5dxd PUTATIVE
BETA-GLUCANASE
(Mycobacteroides
abscessus) 		4 / 8 TRP A 129
ASP A 196
ARG A 115
ASP A 252
 None
None
None
NA  A 300 (-3.2A)
 1.22A 6mn4A-5dxdA:
undetectable		 6mn4A-5dxdA:
21.07