SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 8 ASP A 205
ASN A  65
THR A 439
GLY A 436
 None
 0.71A 1jr1B-5dxfA:
undetectable		 1jr1B-5dxfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 5 VAL A 383
SER A 380
ASP A 338
GLN A 348
 None
 1.23A 1n2xB-5dxfA:
undetectable		 1n2xB-5dxfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 5 LEU A 427
MET A 490
LEU A 491
GLN A 448
 None
 1.39A 1p93D-5dxfA:
undetectable		 1p93D-5dxfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 ARG A 339
GLU A 153
TYR A 206
TYR A 207
VAL A 230
 None
 1.50A 1x70A-5dxfA:
undetectable		 1x70A-5dxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		3 / 3 ARG A 142
SER A 378
TYR A 377
 None
 0.53A 1x70A-5dxfA:
2.1		 1x70A-5dxfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 6 VAL A 230
LEU A 228
PHE A 232
MET A 251
 None
 1.11A 1x8vA-5dxfA:
undetectable		 1x8vA-5dxfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 PHE A 259
PHE A 226
ALA A 254
ILE A 523
PHE A 519
 None
 1.45A 3t3qA-5dxfA:
undetectable		 3t3qA-5dxfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 PHE A 259
PHE A 226
ALA A 254
ILE A 523
PHE A 519
 None
 1.46A 3t3qB-5dxfA:
undetectable		 3t3qB-5dxfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 PHE A 259
PHE A 226
ALA A 254
ILE A 523
PHE A 519
 None
 1.42A 3t3qC-5dxfA:
undetectable		 3t3qC-5dxfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 PHE A 259
PHE A 226
ALA A 254
ILE A 523
PHE A 519
 None
 1.45A 3t3qD-5dxfA:
undetectable		 3t3qD-5dxfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 ARG A 339
GLU A 153
TYR A 206
TYR A 207
VAL A 230
 None
 1.40A 4ffwB-5dxfA:
5.5		 4ffwB-5dxfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 5 GLN A 410
HIS A 408
GLU A 384
LEU A 340
 None
 1.42A 4ig5A-5dxfA:
undetectable		 4ig5A-5dxfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 5 ILE A 299
PHE A 160
SER A  66
ASP A 435
 None
 1.31A 4rzvB-5dxfA:
undetectable		 4rzvB-5dxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 7 SER A  66
GLU A 443
ASP A 435
THR A 463
 None
 1.32A 4uacA-5dxfA:
undetectable		 4uacA-5dxfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 5 ARG A 216
GLN A 213
PRO A 212
ILE A 224
 None
 1.42A 5ki6A-5dxfA:
3.8		 5ki6A-5dxfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 11 ILE A 334
ASP A 338
LEU A 350
GLY A 345
SER A 432
 None
 0.95A 6ieyA-5dxfA:
3.0
6ieyB-5dxfA:
5.2		 6ieyA-5dxfA:
21.75
6ieyB-5dxfA:
21.75