SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 LEU A 228
LEU A 291
ALA A 295
ILE A  61
ILE A  49
 None
 0.74A 1fk6A-5dxiA:
undetectable		 1fk6A-5dxiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 9 LEU A  23
GLU A 190
ILE A 244
VAL A 263
MET A 225
 None
 1.41A 1gx8A-5dxiA:
undetectable		 1gx8A-5dxiA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		3 / 3 ARG A 143
ARG A 142
PRO A  37
 None
TRE  A 403 (-3.8A)
TRE  A 403 (-4.0A)
 1.07A 2wljA-5dxiA:
3.1		 2wljA-5dxiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 LEU A 281
VAL A 268
SER A  17
PHE A  22
ASN A  59
 None
 1.45A 2y00B-5dxiA:
undetectable		 2y00B-5dxiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 LEU A 281
VAL A 268
SER A  17
PHE A  22
ASN A  59
 None
 1.49A 2y01B-5dxiA:
undetectable		 2y01B-5dxiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 7 ASP A 230
GLY A  66
THR A  29
LYS A 188
 MG  A 401 (-2.6A)
TRE  A 403 ( 3.4A)
None
BEF  A 402 (-2.7A)
 1.07A 3vnsA-5dxiA:
undetectable		 3vnsA-5dxiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		3 / 3 GLN A  60
ASP A  93
GLN A 204
 None
 0.61A 4aztA-5dxiA:
2.9		 4aztA-5dxiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 ILE A  64
ASP A 234
LEU A  46
ILE A  63
THR A 233
 None
MG  A 401 ( 4.2A)
None
None
BEF  A 402 ( 4.6A)
 1.24A 4km0A-5dxiA:
2.5		 4km0A-5dxiA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 LEU A  10
LEU A   5
LEU A 281
LEU A 228
LEU A 226
 None
 1.05A 4z91A-5dxiA:
undetectable
4z91B-5dxiA:
undetectable
4z91C-5dxiA:
undetectable
4z91D-5dxiA:
undetectable
4z91E-5dxiA:
undetectable		 4z91A-5dxiA:
19.94
4z91B-5dxiA:
19.94
4z91C-5dxiA:
19.94
4z91D-5dxiA:
19.94
4z91E-5dxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 LEU A 226
LEU A  10
LEU A   5
LEU A 281
LEU A 228
 None
 1.04A 4z91A-5dxiA:
undetectable
4z91B-5dxiA:
undetectable
4z91C-5dxiA:
undetectable
4z91D-5dxiA:
undetectable
4z91E-5dxiA:
undetectable		 4z91A-5dxiA:
19.94
4z91B-5dxiA:
19.94
4z91C-5dxiA:
19.94
4z91D-5dxiA:
19.94
4z91E-5dxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 10 LEU A 281
LEU A 228
LEU A 226
LEU A  10
LEU A   5
 None
 0.98A 4z91A-5dxiA:
undetectable
4z91B-5dxiA:
undetectable
4z91C-5dxiA:
undetectable
4z91D-5dxiA:
undetectable
4z91E-5dxiA:
undetectable		 4z91A-5dxiA:
19.94
4z91B-5dxiA:
19.94
4z91C-5dxiA:
19.94
4z91D-5dxiA:
19.94
4z91E-5dxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 LEU A  11
LEU A 226
GLY A 296
ALA A 295
LEU A  53
 None
 1.01A 5jw1B-5dxiA:
undetectable		 5jw1B-5dxiA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		5 / 12 ALA A 295
GLY A 292
GLN A 286
GLU A 283
LEU A 281
 None
 1.26A 5nwuA-5dxiA:
undetectable		 5nwuA-5dxiA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 5 VAL A 287
LEU A 226
CYH A 227
ASP A 230
 None
None
None
MG  A 401 (-2.6A)
 1.32A 5vcvA-5dxiA:
undetectable		 5vcvA-5dxiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 4 SER A  65
THR A 138
ASP A 115
ASP A  68
 BEF  A 402 ( 2.4A)
TRE  A 403 ( 3.9A)
None
None
 1.44A 5vimA-5dxiA:
undetectable		 5vimA-5dxiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Candida
albicans) 		4 / 4 SER A  65
THR A 138
ASP A 115
ASP A  68
 BEF  A 402 ( 2.4A)
TRE  A 403 ( 3.9A)
None
None
 1.46A 5vimB-5dxiA:
undetectable		 5vimB-5dxiA:
23.67