SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		4 / 6 GLU A 131
LEU A 137
VAL A 114
MET A 115
 None
 0.82A 1hk1A-5dxlA:
2.7		 1hk1A-5dxlA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		5 / 11 ILE A 264
THR A 263
LEU A 267
VAL A  60
PHE A 209
 None
 1.34A 1tw4A-5dxlA:
undetectable		 1tw4A-5dxlA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		4 / 5 GLU A  80
THR A  48
LEU A  52
LEU A  49
 None
 0.90A 1u18B-5dxlA:
undetectable		 1u18B-5dxlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		5 / 12 LEU A  46
LEU A  49
LEU A  52
ALA A  53
LEU A  83
 None
 0.98A 1ya3C-5dxlA:
undetectable		 1ya3C-5dxlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		3 / 3 THR A 138
ASN A 178
GLU A 180
 None
 0.78A 3v4tA-5dxlA:
undetectable
3v4tC-5dxlA:
undetectable		 3v4tA-5dxlA:
20.67
3v4tC-5dxlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		4 / 8 LEU A 211
SER A 238
PHE A 223
ASP A  24
 None
 0.98A 4drjB-5dxlA:
2.5		 4drjB-5dxlA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		5 / 12 LEU A  46
LEU A  49
LEU A  52
ALA A  53
LEU A  83
 None
 0.88A 4ltwA-5dxlA:
undetectable		 4ltwA-5dxlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		5 / 12 GLU A 171
VAL A 170
PRO A 183
SER A  84
GLY A  65
 None
 1.34A 4q15A-5dxlA:
4.6		 4q15A-5dxlA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		5 / 12 GLU A 171
VAL A 170
PRO A 183
SER A  84
GLY A  65
 None
 1.35A 4q15B-5dxlA:
4.5		 4q15B-5dxlA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		5 / 12 GLU A 171
VAL A 170
PRO A 183
SER A  84
GLY A  65
 None
 1.34A 5f9zB-5dxlA:
3.7		 5f9zB-5dxlA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
(Aspergillus
fumigatus) 		4 / 5 VAL A 260
LEU A 211
CYH A 212
ASP A 215
 None
 1.35A 5vcvA-5dxlA:
undetectable		 5vcvA-5dxlA:
21.86