SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 LEU A 323
ALA A 327
THR A 312
LEU A  18
ARG A  21
None
1.23A 1cbrA-5dxxA:
undetectable
1cbrA-5dxxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 LEU A 323
ALA A 327
THR A 312
LEU A  18
ARG A  21
None
1.22A 1cbrB-5dxxA:
undetectable
1cbrB-5dxxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 10 THR A  60
PRO A  73
GLY A  74
PHE A 174
GLY A  83
None
1.25A 1h4oA-5dxxA:
undetectable
1h4oB-5dxxA:
undetectable
1h4oA-5dxxA:
18.85
1h4oB-5dxxA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 9 THR A  60
PRO A  73
GLY A  74
PHE A 174
GLY A  83
None
1.27A 1h4oC-5dxxA:
undetectable
1h4oD-5dxxA:
undetectable
1h4oC-5dxxA:
18.85
1h4oD-5dxxA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 9 THR A  60
PRO A  73
GLY A  74
PHE A 174
GLY A  83
None
1.27A 1h4oE-5dxxA:
undetectable
1h4oF-5dxxA:
undetectable
1h4oE-5dxxA:
18.85
1h4oF-5dxxA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 9 THR A  28
HIS A 180
HIS A 183
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 (-3.4A)
FMN  A7401 (-4.5A)
None
FMN  A7401 (-4.0A)
0.33A 1h60A-5dxxA:
52.8
1h60A-5dxxA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 5 PHE A  99
GLY A 230
SER A 221
THR A 226
None
1.36A 1icuC-5dxxA:
undetectable
1icuD-5dxxA:
undetectable
1icuC-5dxxA:
20.64
1icuD-5dxxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 5 PHE A  99
GLY A 230
SER A 221
THR A 226
None
1.32A 1icvA-5dxxA:
undetectable
1icvB-5dxxA:
undetectable
1icvA-5dxxA:
20.64
1icvB-5dxxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 6 ASN A 196
ASP A 197
THR A 124
PRO A 149
None
0.91A 1n4fA-5dxxA:
undetectable
1n4fA-5dxxA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 9 THR A  28
HIS A 180
HIS A 183
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 (-3.4A)
FMN  A7401 (-4.5A)
None
FMN  A7401 (-4.0A)
0.35A 2abaA-5dxxA:
53.0
2abaA-5dxxA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 11 ARG A 228
GLY A 230
LEU A 335
PHE A  54
TYR A  11
None
1.15A 2azyA-5dxxA:
undetectable
2azyA-5dxxA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 8 ASP A 188
SER A 234
HIS A 239
HIS A 183
None
None
None
FMN  A7401 (-4.5A)
1.33A 2bteD-5dxxA:
undetectable
2bteD-5dxxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 HIS A 183
ASP A 188
GLY A 181
HIS A 180
GLU A 178
FMN  A7401 (-4.5A)
None
None
FMN  A7401 (-3.4A)
None
1.24A 2pgfA-5dxxA:
7.8
2pgfA-5dxxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 PHE A  54
ALA A 165
ALA A 223
VAL A 229
GLY A 230
None
1.11A 2ve3B-5dxxA:
undetectable
2ve3B-5dxxA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 10 THR A  60
PRO A  73
GLY A  74
PHE A 174
GLY A  83
None
1.23A 2vl2A-5dxxA:
undetectable
2vl2C-5dxxA:
undetectable
2vl2A-5dxxA:
18.21
2vl2C-5dxxA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 LEU A 272
ILE A  62
VAL A 159
LEU A 187
PHE A 212
None
1.13A 2zzmA-5dxxA:
undetectable
2zzmA-5dxxA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 PRO A  73
ASN A  38
ILE A  98
PRO A  26
LEU A  24
None
None
None
FMN  A7401 (-3.8A)
None
1.29A 3a51B-5dxxA:
undetectable
3a51B-5dxxA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 PHE A 313
MET A 302
LEU A 301
GLY A 251
LEU A 258
None
1.10A 3i5uA-5dxxA:
undetectable
3i5uA-5dxxA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 9 THR A  28
HIS A 180
HIS A 183
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 (-3.4A)
FMN  A7401 (-4.5A)
None
FMN  A7401 (-4.0A)
0.35A 3upwA-5dxxA:
48.6
3upwA-5dxxA:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 5 ASP A 370
GLY A 374
ASP A 377
THR A 376
None
1.26A 3vqrB-5dxxA:
undetectable
3vqrB-5dxxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 6 TYR A 367
ARG A  31
ASP A 362
TYR A 375
FMN  A7401 (-4.0A)
None
None
None
1.21A 3wfaA-5dxxA:
8.2
3wfaB-5dxxA:
1.8
3wfaA-5dxxA:
19.67
3wfaB-5dxxA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 7 THR A  28
TRP A 103
HIS A 180
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 ( 4.9A)
FMN  A7401 (-3.4A)
None
FMN  A7401 (-4.0A)
0.25A 4a3uA-5dxxA:
53.8
4a3uA-5dxxA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 7 THR A  28
TRP A 103
HIS A 180
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 ( 4.9A)
FMN  A7401 (-3.4A)
None
FMN  A7401 (-4.0A)
0.27A 4a3uB-5dxxA:
53.9
4a3uB-5dxxA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 7 ASP A 188
SER A 234
HIS A 239
HIS A 183
None
None
None
FMN  A7401 (-4.5A)
1.31A 4arcA-5dxxA:
undetectable
4arcA-5dxxA:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 7 THR A  28
TRP A 103
HIS A 180
TYR A 185
FMN  A7401 (-3.9A)
FMN  A7401 ( 4.9A)
FMN  A7401 (-3.4A)
None
0.31A 4awuA-5dxxA:
54.3
4awuA-5dxxA:
39.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 6 THR A  28
HIS A 180
HIS A 183
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 (-3.4A)
FMN  A7401 (-4.5A)
None
FMN  A7401 (-4.0A)
0.33A 4df2A-5dxxA:
48.6
4df2A-5dxxA:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 PHE A  54
GLY A  52
ALA A  51
ASN A  17
TYR A 271
None
1.11A 4rtpA-5dxxA:
undetectable
4rtpA-5dxxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 LEU A  55
ALA A 337
MET A  13
LEU A  18
PHE A 342
None
1.49A 4udaA-5dxxA:
undetectable
4udaA-5dxxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 4 GLY A 324
VAL A 328
PHE A  54
ILE A 314
None
1.14A 4xv2B-5dxxA:
undetectable
4xv2B-5dxxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 4 LEU A 186
GLY A 106
SER A 122
SER A 123
None
1.14A 5uunB-5dxxA:
undetectable
5uunB-5dxxA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 8 THR A  28
TRP A 103
HIS A 180
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 ( 4.9A)
FMN  A7401 (-3.4A)
None
FMN  A7401 (-4.0A)
0.34A 5v4vA-5dxxA:
50.9
5v4vA-5dxxA:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 8 THR A  28
TRP A 103
HIS A 180
TYR A 185
TYR A 367
FMN  A7401 (-3.9A)
FMN  A7401 ( 4.9A)
FMN  A7401 (-3.4A)
None
FMN  A7401 (-4.0A)
0.34A 5v4vB-5dxxA:
50.9
5v4vB-5dxxA:
38.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 6 HIS A  20
ASN A  17
VAL A  97
LEU A  55
None
1.32A 5xdhA-5dxxA:
undetectable
5xdhC-5dxxA:
undetectable
5xdhA-5dxxA:
10.59
5xdhC-5dxxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 5 HIS A  20
ASN A  17
VAL A  97
LEU A  55
None
1.32A 5xdhB-5dxxA:
undetectable
5xdhB-5dxxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 6 HIS A  20
ASN A  17
VAL A  97
LEU A  55
None
1.27A 5xdhA-5dxxA:
undetectable
5xdhC-5dxxA:
undetectable
5xdhA-5dxxA:
10.59
5xdhC-5dxxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 5 HIS A  20
ASN A  17
VAL A  97
LEU A  55
None
1.36A 5xdhD-5dxxA:
undetectable
5xdhD-5dxxA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
4 / 7 ALA A 182
GLY A 181
LEU A 187
GLY A 251
None
0.70A 6nm4A-5dxxA:
undetectable
6nm4A-5dxxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 ILE A  98
LEU A  18
GLY A 176
PHE A 174
ILE A  56
None
1.14A 6qyaB-5dxxA:
undetectable
6qyaB-5dxxA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia
annua)
5 / 12 ILE A  98
LEU A  18
GLY A 176
PHE A 174
ILE A  56
None
1.13A 6qyaD-5dxxA:
undetectable
6qyaD-5dxxA:
23.43