SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_B_CCSB47_0 (GLUTATHIONE S-TRANSFERASE)	5dyj	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	5 / 7	LEU A 636 THR A 640 LEU A 600 GLY A 601 LEU A 562	None	1.42A	1gtiB-5dyjA: undetectable	1gtiB-5dyjA: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJO_A_ERYA1101_0 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	5dyj	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	5 / 12	SER A 691 ALA A 655 ASP A 766 GLU A 713 THR A 765	None None AMP A 904 (-3.1A) AMP A 904 (-3.9A) AMP A 904 ( 4.4A)	1.25A	4zjoA-5dyjA: undetectable	4zjoA-5dyjA: 13.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_A_ADNA1002_1 (MYOSIN HEAVY CHAIN KINASE A)	5dyj	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	11 / 11	PHE A 586 ALA A 587 GLY A 589 VAL A 643 LYS A 645 LEU A 689 GLU A 713 LEU A 715 LEU A 716 PHE A 720 THR A 765	AMP A 904 (-4.8A) AMP A 904 (-3.3A) AMP A 904 (-3.2A) None AMP A 904 (-2.9A) None AMP A 904 (-3.9A) AMP A 904 ( 4.8A) AMP A 904 (-3.8A) AMP A 904 (-3.6A) AMP A 904 ( 4.4A)	0.23A	4zmeA-5dyjA: 41.2	4zmeA-5dyjA: 98.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_B_ADNB902_1 (MYOSIN HEAVY CHAIN KINASE A)	5dyj	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	10 / 10	PHE A 586 ALA A 587 VAL A 643 LYS A 645 LEU A 689 GLU A 713 LEU A 715 LEU A 716 PHE A 720 THR A 765	AMP A 904 (-4.8A) AMP A 904 (-3.3A) None AMP A 904 (-2.9A) None AMP A 904 (-3.9A) AMP A 904 ( 4.8A) AMP A 904 (-3.8A) AMP A 904 (-3.6A) AMP A 904 ( 4.4A)	0.17A	4zmeB-5dyjA: 41.0	4zmeB-5dyjA: 98.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ZME_B_ADNB902_1 (MYOSIN HEAVY CHAIN KINASE A)	5dyj	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	6 / 10	PHE A 586 ALA A 594 LEU A 715 LEU A 716 PHE A 720 THR A 765	AMP A 904 (-4.8A) AMP A 904 ( 4.0A) AMP A 904 ( 4.8A) AMP A 904 (-3.8A) AMP A 904 (-3.6A) AMP A 904 ( 4.4A)	1.39A	4zmeB-5dyjA: 41.0	4zmeB-5dyjA: 98.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AN0_A_HISA520_0 (HISTIDINOL DEHYDROGENASE)	5dyj	MYOSIN HEAVY CHAIN KINASE A (Dictyostelium discoideum)	4 / 6	ARG A 592 GLU A 593 ALA A 594 LYS A 645	AMP A 904 (-3.9A) None AMP A 904 ( 4.0A) AMP A 904 (-2.9A)	0.46A	6an0A-5dyjA: undetectable	6an0A-5dyjA: 21.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTI_B_CCSB47_0","GLUTATHIONE S-TRANSFERASE","5dyj","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",5,"LEU A 636;THR A 640;LEU A 600;GLY A 601;LEU A 562","None","1.42A","1gtiB-5dyjA:undetectable","1gtiB-5dyjA:20.89"],["4ZJO_A_ERYA1101_0","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","5dyj","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",5,"SER A 691;ALA A 655;ASP A 766;GLU A 713;THR A 765","None;None;AMP A 904 (-3.1A);AMP A 904 (-3.9A);AMP A 904 ( 4.4A)","1.25A","4zjoA-5dyjA:undetectable","4zjoA-5dyjA:13.82"],["4ZME_A_ADNA1002_1","MYOSIN HEAVY CHAIN KINASE A","5dyj","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",11,"PHE A 586;ALA A 587;GLY A 589;VAL A 643;LYS A 645;LEU A 689;GLU A 713;LEU A 715;LEU A 716;PHE A 720;THR A 765","AMP A 904 (-4.8A);AMP A 904 (-3.3A);AMP A 904 (-3.2A);None;AMP A 904 (-2.9A);None;AMP A 904 (-3.9A);AMP A 904 ( 4.8A);AMP A 904 (-3.8A);AMP A 904 (-3.6A);AMP A 904 ( 4.4A)","0.23A","4zmeA-5dyjA:41.2","4zmeA-5dyjA:98.37"],["4ZME_B_ADNB902_1","MYOSIN HEAVY CHAIN KINASE A","5dyj","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",10,"PHE A 586;ALA A 587;VAL A 643;LYS A 645;LEU A 689;GLU A 713;LEU A 715;LEU A 716;PHE A 720;THR A 765","AMP A 904 (-4.8A);AMP A 904 (-3.3A);None;AMP A 904 (-2.9A);None;AMP A 904 (-3.9A);AMP A 904 ( 4.8A);AMP A 904 (-3.8A);AMP A 904 (-3.6A);AMP A 904 ( 4.4A)","0.17A","4zmeB-5dyjA:41.0","4zmeB-5dyjA:98.37"],["4ZME_B_ADNB902_1","MYOSIN HEAVY CHAIN KINASE A","5dyj","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",6,"PHE A 586;ALA A 594;LEU A 715;LEU A 716;PHE A 720;THR A 765","AMP A 904 (-4.8A);AMP A 904 ( 4.0A);AMP A 904 ( 4.8A);AMP A 904 (-3.8A);AMP A 904 (-3.6A);AMP A 904 ( 4.4A)","1.39A","4zmeB-5dyjA:41.0","4zmeB-5dyjA:98.37"],["6AN0_A_HISA520_0","HISTIDINOL DEHYDROGENASE","5dyj","MYOSIN HEAVY CHAIN KINASE A","Dictyostelium discoideum",4,"ARG A 592;GLU A 593;ALA A 594;LYS A 645","AMP A 904 (-3.9A);None;AMP A 904 ( 4.0A);AMP A 904 (-2.9A)","0.46A","6an0A-5dyjA:undetectable","6an0A-5dyjA:21.63"]]