SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 ASP A  55
TRP A 319
TYR A 326
ARG A 236
 None
None
212  A 404 (-4.3A)
212  A 404 (-3.1A)
 1.49A 1cebB-5dz2A:
undetectable		 1cebB-5dz2A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 4 GLU A 171
MET A 163
LEU A 166
SER A 167
 None
 1.46A 1ee2B-5dz2A:
undetectable		 1ee2B-5dz2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 MET A 163
LEU A 166
SER A 167
 None
 0.58A 1ee2A-5dz2A:
undetectable		 1ee2A-5dz2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 8 ASP A  86
GLU A 241
SER A 233
ASP A 230
 MG  A 401 (-2.5A)
MG  A 403 ( 4.3A)
MG  A 402 ( 2.5A)
None
 0.87A 1m4iA-5dz2A:
undetectable		 1m4iA-5dz2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 TRP A 164
LEU A 166
LYS A  94
 None
None
MG  A 401 ( 4.1A)
 1.46A 1yajK-5dz2A:
0.4		 1yajK-5dz2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 ARG A 322
LEU A  58
THR A  63
 None
 0.90A 3oxcA-5dz2A:
undetectable		 3oxcA-5dz2A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 6 HIS A  54
GLU A 237
ASP A  87
GLU A 161
 None
MG  A 402 ( 2.7A)
None
None
 0.97A 3vywA-5dz2A:
undetectable		 3vywA-5dz2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 MET A 183
GLU A 161
GLU A 243
GLU A 237
 None
None
None
MG  A 402 ( 2.7A)
 1.24A 4mj8C-5dz2A:
undetectable		 4mj8C-5dz2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 5 PHE A  84
HIS A 105
LEU A 159
PRO A 110
 None
 1.42A 4o8zA-5dz2A:
undetectable		 4o8zA-5dz2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 6 MET A 183
GLU A 161
GLU A 243
GLU A 237
 None
None
None
MG  A 402 ( 2.7A)
 1.28A 4r87H-5dz2A:
undetectable		 4r87H-5dz2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 MET A 183
GLU A 161
GLU A 243
GLU A 237
 None
None
None
MG  A 402 ( 2.7A)
 1.15A 4r87I-5dz2A:
undetectable		 4r87I-5dz2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 MET A 183
GLU A 161
GLU A 243
GLU A 237
 None
None
None
MG  A 402 ( 2.7A)
 1.24A 4r87J-5dz2A:
undetectable
4r87L-5dz2A:
undetectable		 4r87J-5dz2A:
19.29
4r87L-5dz2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A  56
ALA A  17
ALA A  61
TRP A 312
GLY A 316
 None
 1.43A 4rn6A-5dz2A:
undetectable		 4rn6A-5dz2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 SER A 233
ASN A 246
SER A 222
ASP A  86
GLU A 241
 MG  A 402 ( 2.5A)
None
None
MG  A 401 (-2.5A)
MG  A 403 ( 4.3A)
 1.22A 4zjoA-5dz2A:
undetectable		 4zjoA-5dz2A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		6 / 10 ASP A  86
ARG A 184
ASN A 229
SER A 233
GLU A 237
ARG A 325
 MG  A 401 (-2.5A)
212  A 404 (-3.6A)
MG  A 402 ( 2.6A)
MG  A 402 ( 2.5A)
MG  A 402 ( 2.7A)
212  A 404 (-4.0A)
 0.71A 5ermA-5dz2A:
23.0		 5ermA-5dz2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		6 / 10 ASP A  86
ASN A 229
SER A 233
GLU A 237
ARG A 325
TYR A 326
 MG  A 401 (-2.5A)
MG  A 402 ( 2.6A)
MG  A 402 ( 2.5A)
MG  A 402 ( 2.7A)
212  A 404 (-4.0A)
212  A 404 (-4.3A)
 0.52A 5ermA-5dz2A:
23.0		 5ermA-5dz2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		7 / 9 ASP A  86
ARG A 184
ASN A 229
SER A 233
GLU A 237
ARG A 325
TYR A 326
 MG  A 401 (-2.5A)
212  A 404 (-3.6A)
MG  A 402 ( 2.6A)
MG  A 402 ( 2.5A)
MG  A 402 ( 2.7A)
212  A 404 (-4.0A)
212  A 404 (-4.3A)
 0.66A 5ermB-5dz2A:
10.9		 5ermB-5dz2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 TYR A  93
LEU A 132
LEU A 109
HIS A 105
LEU A 159
 None
 1.17A 5v0vA-5dz2A:
1.6		 5v0vA-5dz2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE
(Streptomyces
coelicolor) 		4 / 6 PHE A 277
LEU A 217
ALA A 281
THR A 201
 None
 0.81A 6f88A-5dz2A:
1.0		 6f88A-5dz2A:
13.84