SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 THR A  28
ALA A  31
ASP A  32
LEU A  35
LEU A  67
 None
 1.21A 1errA-5dz6A:
undetectable		 1errA-5dz6A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 GLY A 162
GLY A 123
ILE A 160
ALA A 125
SER A 194
 None
 1.14A 1ri4A-5dz6A:
undetectable		 1ri4A-5dz6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 LEU A  51
ASN A  52
LEU A  88
ARG A 112
MET A  16
 None
 1.15A 2oaxA-5dz6A:
undetectable		 2oaxA-5dz6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 SER A 217
ILE A 218
PRO A 219
PHE A  82
ILE A  73
 None
 0.91A 3clbB-5dz6A:
undetectable		 3clbB-5dz6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 LEU A  51
ASN A  52
LEU A  88
ARG A 112
MET A  16
 None
 1.18A 3vhuA-5dz6A:
undetectable		 3vhuA-5dz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		4 / 8 LEU A  94
TYR A 229
VAL A 246
GLY A  89
 None
 0.74A 4eq4B-5dz6A:
undetectable		 4eq4B-5dz6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 ILE A 119
GLY A 162
GLY A 122
ILE A 160
SER A 194
 None
 1.14A 4iv0B-5dz6A:
undetectable		 4iv0B-5dz6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		4 / 8 GLN A 134
MET A 182
VAL A 180
THR A 181
 None
 1.09A 4lnwA-5dz6A:
undetectable		 4lnwA-5dz6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		4 / 5 THR A  57
THR A  54
HIS A  86
ASN A  65
 CL  A 305 ( 4.0A)
CL  A 305 (-4.2A)
GOL  A 301 (-4.7A)
None
 1.30A 4pgfB-5dz6A:
undetectable		 4pgfB-5dz6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 THR A  28
ALA A  31
ASP A  32
LEU A 106
LEU A  67
 None
 1.02A 4xi3B-5dz6A:
undetectable		 4xi3B-5dz6A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		4 / 6 ILE A 149
ALA A 125
VAL A 127
VAL A 147
 None
 0.90A 5eclD-5dz6A:
undetectable		 5eclD-5dz6A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 ALA A  93
GLN A  12
PHE A   6
GLY A   8
THR A  57
 None
None
None
None
CL  A 305 ( 4.0A)
 1.23A 5hfjB-5dz6A:
undetectable		 5hfjB-5dz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 ALA A  93
GLN A  12
PHE A   6
GLY A   8
THR A  57
 None
None
None
None
CL  A 305 ( 4.0A)
 1.32A 5hfjC-5dz6A:
undetectable		 5hfjC-5dz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 VAL A 271
GLN A 157
ILE A 149
ALA A 150
VAL A 152
 None
BR  A 303 ( 4.6A)
None
None
None
 1.16A 5n0sB-5dz6A:
undetectable		 5n0sB-5dz6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		4 / 8 ILE A  39
LEU A  42
LEU A  51
PRO A  59
 None
 0.86A 5u4sB-5dz6A:
undetectable		 5u4sB-5dz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		3 / 3 GLU A 103
LEU A 106
ARG A 110
 None
 0.52A 6d8fA-5dz6A:
undetectable		 6d8fA-5dz6A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		5 / 12 SER A  87
VAL A 159
HIS A 193
ALA A  84
TYR A 254
 GOL  A 301 (-3.6A)
None
GOL  A 301 (-4.2A)
None
None
 1.13A 6djzC-5dz6A:
undetectable		 6djzC-5dz6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC
(Bacillus
subtilis) 		4 / 8 ARG A  41
GLY A  36
LEU A  35
ALA A  31
 None
 0.76A 6mdqA-5dz6A:
undetectable		 6mdqA-5dz6A:
15.04