SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 11 GLY A  17
LEU A  20
GLY A 267
TYR A  24
GLU A  75
 None
 1.24A 1iolA-5dz7A:
undetectable		 1iolA-5dz7A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 GLY A 162
GLY A 123
ILE A 160
ALA A 125
SER A 194
 None
 1.12A 1ri4A-5dz7A:
undetectable		 1ri4A-5dz7A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		3 / 3 LEU A  27
LEU A 106
MET A  95
 None
 0.78A 1ya3B-5dz7A:
undetectable		 1ya3B-5dz7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		3 / 3 VAL A 149
ASN A 153
TRP A 248
 None
 1.12A 2y00B-5dz7A:
undetectable		 2y00B-5dz7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		4 / 7 ILE A 167
LEU A 139
THR A 245
THR A 177
 None
 1.09A 3nxuA-5dz7A:
undetectable		 3nxuA-5dz7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 THR A  54
PHE A 192
ILE A 119
SER A 189
HIS A  53
 None
GOL  A 303 (-4.2A)
None
None
None
 1.26A 4c49C-5dz7A:
undetectable		 4c49C-5dz7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 THR A  54
PHE A 192
ILE A 119
SER A 189
HIS A  53
 None
GOL  A 303 (-4.2A)
None
None
None
 1.22A 4c49D-5dz7A:
undetectable		 4c49D-5dz7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		4 / 8 LEU A  94
TYR A 229
VAL A 246
GLY A  89
 None
 0.67A 4eq4B-5dz7A:
undetectable		 4eq4B-5dz7A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		6 / 12 VAL A 159
ILE A 119
GLY A 162
GLY A 122
ILE A 147
SER A 194
 None
 1.44A 4iv0A-5dz7A:
undetectable		 4iv0A-5dz7A:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 ILE A 119
GLY A 162
GLY A 122
ILE A 160
SER A 194
 None
 1.12A 4iv0B-5dz7A:
undetectable		 4iv0B-5dz7A:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		3 / 3 TRP A 248
GLN A 156
THR A 249
 None
 0.84A 4m2xA-5dz7A:
undetectable		 4m2xA-5dz7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		6 / 12 VAL A 159
ILE A 119
GLY A 162
GLY A 122
ILE A 147
SER A 194
 None
 1.43A 4mwzB-5dz7A:
undetectable		 4mwzB-5dz7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		4 / 5 THR A  57
THR A  54
HIS A  86
ASN A  65
 None
 1.31A 4pgfB-5dz7A:
undetectable		 4pgfB-5dz7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 LEU A 139
LYS A 132
LEU A 130
VAL A 173
ALA A 170
 None
 1.24A 4x1iB-5dz7A:
undetectable		 4x1iB-5dz7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		4 / 8 GLY A   8
TYR A   4
ALA A  83
GLY A  85
 None
 0.83A 5albL-5dz7A:
undetectable		 5albL-5dz7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		4 / 5 THR A 120
GLY A 190
GLU A  55
HIS A  53
 None
 1.14A 5c0oH-5dz7A:
undetectable		 5c0oH-5dz7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 ALA A  93
GLN A  12
PHE A   6
GLY A   8
THR A  57
 None
 1.15A 5hfjB-5dz7A:
undetectable		 5hfjB-5dz7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 ALA A  93
GLN A  12
PHE A   6
GLY A   8
THR A  57
 None
 1.25A 5hfjC-5dz7A:
undetectable		 5hfjC-5dz7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		5 / 12 ALA A  93
GLN A  12
PHE A   6
GLY A   8
THR A  57
 None
 1.29A 5hfjG-5dz7A:
undetectable		 5hfjG-5dz7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE
(Bacillus
subtilis) 		4 / 6 LEU A 234
TYR A  62
ASP A 101
GLN A  30
 None
 1.45A 6djzC-5dz7A:
undetectable		 6djzC-5dz7A:
23.66