SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 4 SER A 243
ILE A 246
VAL A  85
THR A 135
 None
 1.10A 1u70A-5dzsA:
2.0		 1u70A-5dzsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 12 HIS A  20
LEU A 264
TYR A 234
ILE A 241
SER A 255
 None
 1.43A 1xmuA-5dzsA:
undetectable		 1xmuA-5dzsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 12 HIS A  20
LEU A 264
TYR A 234
ILE A 241
SER A 255
 None
 1.45A 1xmuB-5dzsA:
undetectable		 1xmuB-5dzsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 12 HIS A  20
LEU A 264
TYR A 234
ILE A 241
SER A 255
 None
 1.44A 1xoqA-5dzsA:
undetectable		 1xoqA-5dzsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 12 HIS A  20
LEU A 264
TYR A 234
ILE A 241
SER A 255
 None
 1.41A 1xoqB-5dzsA:
undetectable		 1xoqB-5dzsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 12 LEU A 164
ILE A 163
LEU A 124
VAL A 122
GLU A 169
 None
 1.23A 2bxfB-5dzsA:
undetectable		 2bxfB-5dzsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 12 ILE A 123
ALA A 121
SER A 140
LEU A 145
LEU A 209
 None
 1.04A 3dzyA-5dzsA:
undetectable		 3dzyA-5dzsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 7 VAL A 120
LYS A 144
TYR A 146
LYS A 174
 None
 1.14A 3hs4A-5dzsA:
undetectable		 3hs4A-5dzsA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		5 / 9 ILE A 221
ILE A 207
PRO A 194
VAL A 195
ILE A 200
 None
 1.02A 3nu4A-5dzsA:
undetectable		 3nu4A-5dzsA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		6 / 12 VAL A 116
GLY A 141
VAL A 120
ILE A  82
ALA A 133
ALA A 132
 None
 1.24A 3sufD-5dzsA:
undetectable		 3sufD-5dzsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		3 / 3 GLN A 244
PHE A  24
TYR A  33
 None
 0.99A 3ucjA-5dzsA:
undetectable		 3ucjA-5dzsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 6 ASP A 101
ALA A  79
THR A 100
THR A  87
 None
 1.47A 4w5qA-5dzsA:
5.3		 4w5qA-5dzsA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 6 ASP A 101
ALA A  79
THR A 100
THR A  87
 None
 1.45A 4w5tA-5dzsA:
undetectable		 4w5tA-5dzsA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 6 ASP A 101
ALA A  79
THR A 100
THR A  87
 None
 1.44A 4z4cA-5dzsA:
5.2		 4z4cA-5dzsA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 5 ASP A 101
ALA A  79
THR A 100
THR A  87
 None
 1.46A 4z4gA-5dzsA:
4.9		 4z4gA-5dzsA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 6 ASP A 101
ALA A  79
THR A 100
THR A  87
 None
 1.46A 4z4iA-5dzsA:
undetectable		 4z4iA-5dzsA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 6 ALA A 133
SER A 130
SER A 160
ASP A 139
 None
 1.22A 5c6pA-5dzsA:
undetectable		 5c6pA-5dzsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 6 ILE A 177
GLY A 222
ASN A 223
ILE A 178
 None
 0.87A 5j4nB-5dzsA:
undetectable		 5j4nB-5dzsA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		4 / 8 ALA A  84
LEU A  72
ILE A  43
VAL A   7
 None
 0.72A 5nujA-5dzsA:
undetectable		 5nujA-5dzsA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))
(Clostridioides
difficile) 		3 / 3 SER A 198
LYS A 197
SER A 196
 None
 0.76A 6az3P-5dzsA:
undetectable		 6az3P-5dzsA:
17.28