SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 10 ALA A 770
VAL A 798
ILE A 795
GLY A 744
PRO A 749
 None
 1.24A 1d4sA-5dztA:
undetectable		 1d4sA-5dztA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 7 PHE A 289
PHE A 286
PHE A 343
PHE A 369
 None
 0.83A 1lh6A-5dztA:
undetectable		 1lh6A-5dztA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 4 THR A 218
LEU A 222
VAL A 225
LEU A 229
 None
 0.60A 1mz9D-5dztA:
undetectable		 1mz9D-5dztA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 ALA A 988
GLY A 974
GLY A 972
ILE A 703
LEU A 953
 None
 1.10A 1x1aA-5dztA:
undetectable		 1x1aA-5dztA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 5 ILE A 940
ARG A 979
LEU A 977
ASN A 980
 None
 1.18A 1y0xX-5dztA:
undetectable		 1y0xX-5dztA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 5 PRO A 749
VAL A 752
VAL A 706
ILE A 703
 None
 1.05A 1z2bC-5dztA:
undetectable		 1z2bC-5dztA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 7 MET A 518
LEU A  40
PRO A 565
VAL A 552
 None
 1.23A 2hrcA-5dztA:
undetectable		 2hrcA-5dztA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 ARG A 514
ARG A 510
PRO A 511
 None
 1.05A 2wljA-5dztA:
1.9		 2wljA-5dztA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 TYR A 299
GLU A 313
ASN A 237
 None
 1.01A 2y7hC-5dztA:
undetectable		 2y7hC-5dztA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 8 ALA A 355
TYR A 330
ILE A 353
TYR A 333
 None
 1.02A 2zm8A-5dztA:
undetectable		 2zm8A-5dztA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 GLY A 965
GLY A 972
LEU A 690
ASN A 691
TYR A 695
 None
 1.10A 2zw9A-5dztA:
2.2		 2zw9A-5dztA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 GLY A 965
GLY A 972
LEU A 690
ASN A 691
TYR A 695
 None
 1.00A 2zw9B-5dztA:
undetectable		 2zw9B-5dztA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 ASN A  11
GLY A  60
TYR A  53
GLN A  31
TRP A  33
 None
 1.50A 3bwmA-5dztA:
undetectable		 3bwmA-5dztA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 11 ALA A 296
GLY A 334
ILE A 337
ILE A 362
ILE A 298
 None
 1.00A 3ebzA-5dztA:
undetectable		 3ebzA-5dztA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 9 ALA A 770
VAL A 798
ILE A 795
GLY A 744
PRO A 749
 None
 1.08A 3el4B-5dztA:
undetectable		 3el4B-5dztA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 7 LYS A 303
GLU A 312
VAL A 272
VAL A 260
 None
AMP  A1002 (-3.5A)
AMP  A1002 (-4.6A)
AMP  A1002 (-4.2A)
 0.61A 3em0B-5dztA:
undetectable		 3em0B-5dztA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 TYR A 717
PHE A 704
ILE A 970
VAL A 973
ILE A 650
 None
 1.25A 3fpjB-5dztA:
undetectable		 3fpjB-5dztA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 10 SER A 794
LEU A 750
ILE A 769
SER A 738
GLY A 744
 None
 1.35A 3iluB-5dztA:
undetectable
3iluE-5dztA:
undetectable		 3iluB-5dztA:
12.72
3iluE-5dztA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 11 ILE A 769
SER A 738
GLY A 744
SER A 794
LEU A 750
 None
 1.38A 3iluB-5dztA:
undetectable
3iluE-5dztA:
undetectable		 3iluB-5dztA:
12.72
3iluE-5dztA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 ASP A 558
SER A 579
ARG A 256
 None
 0.92A 3loqA-5dztA:
undetectable		 3loqA-5dztA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 9 ALA A 296
GLY A 334
ILE A 337
ILE A 362
ILE A 298
 None
 1.01A 3s45A-5dztA:
undetectable		 3s45A-5dztA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 GLY A  62
LEU A  61
ASN A  29
ALA A 531
PHE A  69
 None
 1.19A 3vywD-5dztA:
undetectable		 3vywD-5dztA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 LEU A 953
GLY A 972
GLY A 969
ILE A 701
ALA A 915
 None
 1.14A 4a6dA-5dztA:
undetectable		 4a6dA-5dztA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 8 ILE A 354
ILE A 363
VAL A 272
GLN A 250
 None
AMP  A1002 ( 3.9A)
AMP  A1002 (-4.6A)
AMP  A1002 (-3.3A)
 0.83A 4acaC-5dztA:
undetectable		 4acaC-5dztA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 GLU A 976
GLY A 916
PHE A 967
TYR A 748
VAL A 706
 None
 1.27A 4ffwB-5dztA:
undetectable		 4ffwB-5dztA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 ARG A 979
TYR A 705
ASN A 757
 None
 0.86A 4ffwB-5dztA:
undetectable		 4ffwB-5dztA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 CYH A 132
ASN A 130
LYS A 134
 None
 0.92A 4k50A-5dztA:
undetectable		 4k50A-5dztA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 LEU A 294
LEU A 290
ILE A 492
ASN A 344
GLY A 338
 None
 0.90A 4lmnA-5dztA:
2.7		 4lmnA-5dztA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 ILE A 271
MET A 221
ARG A 224
 None
 0.69A 4lnwA-5dztA:
undetectable		 4lnwA-5dztA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5dzt CYLM
(Enterococcus
faecalis) 		3 / 3 ILE A 271
MET A 221
ARG A 224
 None
 0.68A 4lnxA-5dztA:
undetectable		 4lnxA-5dztA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 6 ALA A 485
ILE A 393
GLY A 338
ILE A 600
 None
 0.77A 4r21A-5dztA:
undetectable		 4r21A-5dztA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5dzt CYLM
(Enterococcus
faecalis) 		4 / 4 CYH A 654
LEU A 978
LEU A 708
ALA A 707
 None
 1.08A 5hpuA-5dztA:
undetectable
5hpuB-5dztA:
undetectable		 5hpuA-5dztA:
3.35
5hpuB-5dztA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 ASN A  11
GLY A  60
TYR A  53
GLN A  31
TRP A  33
 None
 1.49A 5lsaA-5dztA:
undetectable		 5lsaA-5dztA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 PHE A 286
ILE A 492
PHE A 343
GLY A 338
ILE A 298
 None
 1.10A 5m24A-5dztA:
undetectable		 5m24A-5dztA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5dzt CYLM
(Enterococcus
faecalis) 		5 / 12 GLY A 257
GLN A 146
GLU A 147
LEU A 148
LEU A 151
 None
 0.94A 5nwwA-5dztA:
undetectable		 5nwwA-5dztA:
3.61