SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		5 / 12 ILE A  25
LEU A 173
VAL A 164
LEU A 181
ILE A  24
 GOL  A 201 ( 4.0A)
None
None
None
None
 1.00A 1df7A-5dzuA:
undetectable		 1df7A-5dzuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		4 / 4 LYS A 128
LEU A  80
LEU A  71
SER A  72
 None
 1.46A 1tz8D-5dzuA:
undetectable		 1tz8D-5dzuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		5 / 12 LEU A 173
GLY A  34
VAL A  59
PRO A  61
GLY A  30
 None
 1.03A 3ku1H-5dzuA:
undetectable		 3ku1H-5dzuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		5 / 12 GLY A  34
ARG A  54
GLY A  63
ARG A  29
SER A  26
 None
 1.33A 3tkaA-5dzuA:
undetectable		 3tkaA-5dzuA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		4 / 6 LYS A 128
LEU A  80
LEU A  71
SER A  72
 None
 1.20A 5a6iA-5dzuA:
undetectable		 5a6iA-5dzuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		4 / 6 LYS A 128
LEU A  80
LEU A  71
SER A  72
 None
 1.18A 5l4iB-5dzuA:
undetectable		 5l4iB-5dzuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5dzu ASPARTIC PROTEASE
INHIBITOR 11
(Solanum
tuberosum) 		4 / 8 LEU A 173
VAL A  52
VAL A  36
ILE A  83
 None
 0.73A 5y9mX-5dzuA:
undetectable		 5y9mX-5dzuA:
18.64