SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		5 / 10 ALA A 128
LEU A 163
LEU A 183
VAL A 197
LEU A 111
 None
 1.09A 3jw5B-5dzvA:
undetectable		 3jw5B-5dzvA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 6 LEU A 291
SER A 253
PHE A 252
ILE A 289
 None
 0.94A 3ko0B-5dzvA:
undetectable		 3ko0B-5dzvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 6 LEU A 291
SER A 253
PHE A 252
ILE A 289
 None
 0.95A 3ko0S-5dzvA:
undetectable		 3ko0S-5dzvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 7 ASP A  62
ASP A  99
ASN A 100
GLU A   8
 CA  A 603 (-3.5A)
CA  A 603 ( 3.0A)
CA  A 603 (-4.5A)
CA  A 601 ( 2.9A)
 1.00A 4feuB-5dzvA:
undetectable		 4feuB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 7 ASP A 454
ASP A 333
ASN A 420
GLU A 457
 CA  A 612 (-3.0A)
None
CA  A 612 (-3.5A)
None
 1.16A 4fevB-5dzvA:
undetectable		 4fevB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 7 ASP A 454
ASP A 333
GLU A 457
GLU A 387
 CA  A 612 (-3.0A)
None
None
CA  A 611 ( 2.8A)
 1.20A 4fevB-5dzvA:
undetectable		 4fevB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 7 ASP A 454
ASP A 333
ASN A 420
GLU A 457
 CA  A 612 (-3.0A)
None
CA  A 612 (-3.5A)
None
 1.13A 4fewB-5dzvA:
undetectable		 4fewB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 7 ASP A 454
ASP A 333
GLU A 457
GLU A 387
 CA  A 612 (-3.0A)
None
None
CA  A 611 ( 2.8A)
 1.17A 4fewB-5dzvA:
undetectable		 4fewB-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 SER A 238
ASN A 236
CYH A 305
GLY A 303
 FUC  A 616 ( 4.2A)
NAG  A 615 (-1.9A)
None
None
 1.00A 4fo4A-5dzvA:
undetectable		 4fo4A-5dzvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 ASP A 454
ASP A 333
ASN A 420
GLU A 457
 CA  A 612 (-3.0A)
None
CA  A 612 (-3.5A)
None
 1.15A 4gkhD-5dzvA:
undetectable		 4gkhD-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 ASP A 454
ASP A 333
GLU A 457
GLU A 387
 CA  A 612 (-3.0A)
None
None
CA  A 611 ( 2.8A)
 1.14A 4gkhD-5dzvA:
undetectable		 4gkhD-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 ASP A 172
ASP A 295
GLU A 115
ASP A 239
 CA  A 606 (-2.7A)
CA  A 605 (-3.6A)
CA  A 604 ( 2.6A)
CA  A 605 (-2.6A)
 1.14A 4gkhC-5dzvA:
undetectable
4gkhK-5dzvA:
undetectable		 4gkhC-5dzvA:
20.15
4gkhK-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 ASP A 172
ASP A 295
GLU A 115
ASP A 239
 CA  A 606 (-2.7A)
CA  A 605 (-3.6A)
CA  A 604 ( 2.6A)
CA  A 605 (-2.6A)
 1.14A 4gkiE-5dzvA:
undetectable
4gkiG-5dzvA:
undetectable		 4gkiE-5dzvA:
20.15
4gkiG-5dzvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		5 / 9 GLU A 147
ASN A 146
LEU A 165
LEU A 171
ILE A 113
 None
 1.19A 4r38C-5dzvA:
undetectable		 4r38C-5dzvA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		5 / 12 GLY A 303
SER A 216
ALA A 237
ALA A 293
TYR A 250
 None
 1.45A 4ymgA-5dzvA:
undetectable		 4ymgA-5dzvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		3 / 3 ASN A 236
TYR A 250
CYH A 305
 NAG  A 615 (-1.9A)
None
None
 1.10A 5lsuB-5dzvA:
undetectable		 5lsuB-5dzvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 4 TYR A   4
GLY A  53
ASN A  52
ARG A  18
 None
 1.29A 5w7bA-5dzvA:
undetectable
5w7bC-5dzvA:
undetectable		 5w7bA-5dzvA:
9.20
5w7bC-5dzvA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		5 / 12 GLY A 127
VAL A 160
LEU A 193
GLY A 195
ALA A 137
 None
 1.13A 6c2mA-5dzvA:
undetectable		 6c2mA-5dzvA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5dzv PROTEIN PCDHA7
(Mus
musculus) 		4 / 8 ARG A  60
GLU A   9
ASP A  62
GLU A  65
 None
CA  A 603 (-3.1A)
CA  A 603 (-3.5A)
None
 1.18A 6mn4D-5dzvA:
undetectable		 6mn4D-5dzvA:
20.37