SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5dzw PROTOCADHERIN
ALPHA-4
(Mus
musculus) 		4 / 6 VAL A 166
SER A 150
ARG A 168
LEU A 119
 None
 1.22A 2f8dA-5dzwA:
undetectable		 2f8dA-5dzwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5dzw PROTOCADHERIN
ALPHA-4
(Mus
musculus) 		4 / 6 PHE A 112
ARG A 117
ASN A 209
LEU A 301
 None
None
CA  A 509 ( 3.7A)
None
 1.27A 2nyrA-5dzwA:
undetectable		 2nyrA-5dzwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5dzw PROTOCADHERIN
ALPHA-4
(Mus
musculus) 		4 / 7 LEU A 199
GLN A 198
LEU A 125
PHE A 123
 None
 0.99A 3ag2C-5dzwA:
undetectable		 3ag2C-5dzwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5dzw PROTOCADHERIN
ALPHA-4
(Mus
musculus) 		5 / 10 ALA A 128
LEU A 163
LEU A 183
VAL A 197
LEU A 111
 None
 1.19A 3jw5B-5dzwA:
undetectable		 3jw5B-5dzwA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5dzw PROTOCADHERIN
ALPHA-4
(Mus
musculus) 		3 / 3 ASN A 236
TYR A 250
CYH A 305
 NAG  A 504 (-1.8A)
None
None
 1.04A 5lsuB-5dzwA:
undetectable		 5lsuB-5dzwA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5dzw PROTOCADHERIN
ALPHA-4
(Mus
musculus) 		4 / 6 GLN A 355
VAL A 356
ALA A 398
THR A 397
 None
 0.94A 6cduB-5dzwA:
undetectable
6cduC-5dzwA:
undetectable		 6cduB-5dzwA:
21.68
6cduC-5dzwA:
21.68