SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 8 GLN A  79
LEU A  56
TYR A   5
LEU A  24
 None
 1.13A 1hk3A-5dzxA:
undetectable		 1hk3A-5dzxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 8 ASP A 206
GLY A 244
GLN A 115
GLU A 116
 CA  A 516 (-3.4A)
None
None
CA  A 516 ( 2.9A)
 0.98A 3s3mA-5dzxA:
undetectable		 3s3mA-5dzxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 7 ILE A 272
THR A 283
LEU A 278
VAL A 223
 None
 0.88A 3ua5B-5dzxA:
undetectable		 3ua5B-5dzxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 4 ILE A 245
SER A 295
ASP A 206
ASP A 173
 None
None
CA  A 516 (-3.4A)
CA  A 515 (-2.8A)
 1.29A 4krhB-5dzxA:
undetectable		 4krhB-5dzxA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 6 GLU A 104
ASP A 131
ASP A 133
GLU A  65
 None
CA  A 514 (-2.6A)
CA  A 513 ( 3.3A)
CA  A 513 ( 2.7A)
 1.33A 4ntxA-5dzxA:
undetectable
4ntxC-5dzxA:
undetectable		 4ntxA-5dzxA:
23.11
4ntxC-5dzxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 6 GLU A 213
ASP A 240
ASP A 242
GLU A 175
 None
CA  A 517 (-2.2A)
CA  A 516 ( 3.4A)
CA  A 516 ( 2.8A)
 1.33A 4ntxA-5dzxA:
undetectable
4ntxC-5dzxA:
undetectable		 4ntxA-5dzxA:
23.11
4ntxC-5dzxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 5 VAL A 308
THR A 283
ASP A 279
LEU A 278
 None
None
CA  A 518 (-3.0A)
None
 1.32A 5m0iB-5dzxA:
undetectable		 5m0iB-5dzxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dzx PROTOCADHERIN BETA 6
(Mus
musculus) 		4 / 5 GLU A  52
THR A  53
HIS A  19
LEU A  57
 None
 1.23A 5utuH-5dzxA:
undetectable		 5utuH-5dzxA:
22.99