SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 7 PRO A2175
THR A2045
LEU A2048
VAL A2203
 None
 0.90A 1jgsA-5dzzA:
undetectable		 1jgsA-5dzzA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 5 PRO A2230
VAL A2233
ASN A2234
VAL A2219
 None
 1.04A 1z2bC-5dzzA:
undetectable		 1z2bC-5dzzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 8 ASP A2136
GLY A2095
PHE A2096
ASP A2098
 None
 1.03A 2aouA-5dzzA:
undetectable		 2aouA-5dzzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		3 / 3 VAL A2069
ASP A2070
GLU A2090
 None
 0.50A 2qeuA-5dzzA:
2.6		 2qeuA-5dzzA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		3 / 3 VAL A2069
ASP A2070
GLU A2090
 None
 0.52A 2qeuC-5dzzA:
undetectable		 2qeuC-5dzzA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 5 ILE A2263
PRO A2418
VAL A2336
PHE A2415
 None
 1.06A 2ygnA-5dzzA:
undetectable		 2ygnA-5dzzA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 11 THR A2287
ILE A2263
LEU A2429
ASN A2423
ILE A2260
 None
 1.37A 3a50B-5dzzA:
undetectable		 3a50B-5dzzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 12 PHE A2096
VAL A2107
LEU A2124
ILE A2111
THR A2120
 None
 1.40A 3elzA-5dzzA:
undetectable		 3elzA-5dzzA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 6 LYS A1999
LEU A1994
LYS A1988
LEU A1991
 None
 1.12A 3h5gB-5dzzA:
undetectable
3h5gC-5dzzA:
undetectable		 3h5gB-5dzzA:
5.35
3h5gC-5dzzA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 9 ASP A2060
GLY A2020
ILE A2018
ILE A2086
ILE A2058
 None
 1.00A 3s56B-5dzzA:
undetectable		 3s56B-5dzzA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 6 LEU A2201
ILE A2018
TYR A2183
VAL A2181
 None
 0.72A 4a9kA-5dzzA:
undetectable		 4a9kA-5dzzA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 12 PHE A2172
LEU A2153
GLY A2133
SER A2131
ILE A2129
 None
 1.50A 4djeA-5dzzA:
undetectable		 4djeA-5dzzA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 8 ILE A2073
ILE A2058
LEU A2049
ILE A2086
 None
 0.89A 4dtaB-5dzzA:
undetectable		 4dtaB-5dzzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 12 PHE A2415
ALA A2294
THR A2298
ALA A2373
THR A2374
 None
 0.91A 4fiaA-5dzzA:
undetectable		 4fiaA-5dzzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 12 PHE A2415
ALA A2294
THR A2298
ALA A2373
THR A2374
 None
 0.91A 4fiaA-5dzzA:
undetectable		 4fiaA-5dzzA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 12 TYR A2183
SER A2131
GLN A2128
ALA A2053
ALA A2054
 None
 1.41A 5cxvA-5dzzA:
undetectable		 5cxvA-5dzzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		4 / 8 PRO A2418
ILE A2263
PRO A2304
LEU A2443
 None
 0.87A 5g48A-5dzzA:
undetectable		 5g48A-5dzzA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 12 LEU A2350
GLY A2256
ASP A2252
LEU A2367
ALA A2297
 None
 1.13A 5h5fA-5dzzA:
undetectable		 5h5fA-5dzzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 11 ARG A2385
ASP A2252
SER A2257
ILE A2372
ILE A2377
 None
 1.26A 5y80A-5dzzA:
undetectable		 5y80A-5dzzA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		3 / 3 LYS A1974
VAL A1967
ASP A1969
 None
 0.51A 6fgdA-5dzzA:
undetectable		 6fgdA-5dzzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5dzz DESMOPLAKIN
(Homo
sapiens) 		5 / 11 ILE A2058
LEU A2198
GLY A2016
SER A2131
ALA A2051
 None
 1.19A 6ieyA-5dzzA:
undetectable
6ieyB-5dzzA:
undetectable		 6ieyA-5dzzA:
21.00
6ieyB-5dzzA:
21.00