SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 10 ALA A 535
PHE A 446
LEU A 235
TYR A 297
ILE A 232
 None
None
None
None
A  C   4 ( 3.6A)
 1.21A 1claA-5e02A:
undetectable		 1claA-5e02A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 LEU A 974
LEU A1026
ALA A1007
ALA A1003
LEU A 956
 None
 1.31A 1kt5A-5e02A:
undetectable		 1kt5A-5e02A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 LEU A 840
ILE A 839
ILE A 829
PRO A 838
 None
 0.95A 1oniB-5e02A:
undetectable
1oniC-5e02A:
undetectable		 1oniB-5e02A:
8.92
1oniC-5e02A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 GLN A 573
HIS A 296
ARG A 299
 None
 1.03A 1zlqA-5e02A:
0.0		 1zlqA-5e02A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 ILE A 232
PHE A 552
MET A 591
PHE A 361
ALA A 602
 A  C   4 ( 3.6A)
None
None
None
None
 1.37A 2x2nD-5e02A:
undetectable		 2x2nD-5e02A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 ILE A 521
ILE A1058
LEU A 502
LEU A 485
 None
 0.82A 3adxA-5e02A:
undetectable		 3adxA-5e02A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.98A 3ag1C-5e02A:
undetectable
3ag1J-5e02A:
undetectable		 3ag1C-5e02A:
12.20
3ag1J-5e02A:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 11 LEU A 314
PRO A 231
SER A 230
THR A 270
LYS A 239
 None
None
None
None
ADP  A1201 ( 4.9A)
 1.35A 3bjwE-5e02A:
undetectable		 3bjwE-5e02A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 GLU A1054
VAL A1052
CYH A1047
 None
 1.01A 3fbxA-5e02A:
undetectable		 3fbxA-5e02A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 HIS A 949
PHE A 961
PHE A 962
 None
 0.71A 3lk0D-5e02A:
undetectable		 3lk0D-5e02A:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 GLY A 507
GLY A 505
ALA A 535
LEU A 524
LEU A 533
 None
 1.22A 3mteA-5e02A:
undetectable		 3mteA-5e02A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 GLY A 507
GLY A 505
ALA A 535
LEU A 524
LEU A 533
 None
 1.15A 3p2kB-5e02A:
2.6		 3p2kB-5e02A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 ILE A 777
SER A 784
LYS A 782
GLY A 781
 None
 1.18A 3tkdB-5e02A:
undetectable		 3tkdB-5e02A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 LEU A 199
ILE A 311
CYH A 345
ILE A 337
ILE A 192
 None
 1.37A 3uj7A-5e02A:
undetectable		 3uj7A-5e02A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 ASP A 693
LEU A 856
TYR A 690
GLU A 689
 None
 1.12A 3w9tB-5e02A:
undetectable		 3w9tB-5e02A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 ASP A 693
LEU A 856
TYR A 690
GLU A 689
 None
 1.12A 3w9tE-5e02A:
undetectable		 3w9tE-5e02A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 ASP A 693
LEU A 856
TYR A 690
GLU A 689
 None
 1.14A 3w9tF-5e02A:
undetectable		 3w9tF-5e02A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 8 THR A 538
GLY A 542
GLN A 238
ILE A 541
PRO A 231
 A  C   3 ( 3.2A)
None
None
None
None
 1.32A 4e1vA-5e02A:
undetectable		 4e1vA-5e02A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 GLY A 579
GLY A 587
ASP A 584
LEU A 583
ALA A 575
 None
 0.94A 4lg1A-5e02A:
2.3		 4lg1A-5e02A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 7 ASN A 626
GLU A 309
GLU A 950
ARG A 917
 None
 1.11A 4mi4B-5e02A:
undetectable
4mi4C-5e02A:
undetectable		 4mi4B-5e02A:
11.10
4mi4C-5e02A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 8 ASN A 626
GLU A 309
GLU A 950
ARG A 917
 None
 1.09A 4mj8B-5e02A:
undetectable
4mj8C-5e02A:
undetectable		 4mj8B-5e02A:
9.99
4mj8C-5e02A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 ASP A 820
VAL A 826
ASP A 827
ALA A 787
 None
 1.20A 4nedA-5e02A:
undetectable		 4nedA-5e02A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 HIS A 346
VAL A 198
GLU A 196
VAL A 151
 None
 1.42A 4p6vB-5e02A:
undetectable
4p6vE-5e02A:
undetectable		 4p6vB-5e02A:
16.18
4p6vE-5e02A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 4 ASN A 237
VAL A 257
THR A 269
ILE A 272
 None
None
A  C   4 ( 4.7A)
None
 1.23A 4retA-5e02A:
undetectable		 4retA-5e02A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 4 ASN A 237
VAL A 257
THR A 269
ILE A 272
 None
None
A  C   4 ( 4.7A)
None
 1.23A 4retC-5e02A:
undetectable		 4retC-5e02A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 SER A 124
GLY A 579
ARG A 548
GLY A 587
 None
 0.53A 5cdpA-5e02A:
undetectable
5cdpB-5e02A:
undetectable		 5cdpA-5e02A:
19.01
5cdpB-5e02A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 ASP A 351
ALA A 325
SER A 201
THR A 567
PRO A 328
 None
 1.15A 5hnzB-5e02A:
undetectable		 5hnzB-5e02A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 SER A 264
LEU A 273
MET A 268
 None
 0.85A 5ikrB-5e02A:
undetectable		 5ikrB-5e02A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 5 TYR A 214
SER A 191
ALA A 190
GLN A 185
 None
None
None
ADP  A1201 ( 4.1A)
 1.18A 5n0tA-5e02A:
undetectable		 5n0tA-5e02A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		3 / 3 LYS A1093
TRP A1037
SER A1092
 None
 1.34A 5nwwA-5e02A:
undetectable		 5nwwA-5e02A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		5 / 12 LEU A 371
PHE A 440
ILE A 369
ALA A 575
GLY A 579
 None
 1.03A 5veuA-5e02A:
1.6		 5veuA-5e02A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5e02 FRQ-INTERACTING RNA
HELICASE
(Neurospora
crassa) 		4 / 6 LEU A1015
VAL A 920
ARG A 917
SER A 916
 None
 1.29A 6f6jA-5e02A:
undetectable		 6f6jA-5e02A:
undetectable