SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		4 / 4 LEU A 205
PRO A 325
ILE A 284
LEU A 294
 None
 1.01A 1ya4B-5e04A:
undetectable		 1ya4B-5e04A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		3 / 3 HIS A 394
PHE A 331
PHE A 330
 None
 0.41A 3lk0D-5e04A:
undetectable		 3lk0D-5e04A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		4 / 8 ILE A 236
ILE A 379
PHE A 330
GLY A 388
 None
 0.79A 4hdlA-5e04A:
undetectable		 4hdlA-5e04A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		4 / 7 TYR A 320
ILE A 373
GLY A 323
TYR A 264
 None
 0.82A 4iqqC-5e04A:
undetectable		 4iqqC-5e04A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		4 / 5 TYR A 383
ILE A 381
ASN A 261
TYR A 264
 None
 1.02A 4jtpA-5e04A:
undetectable		 4jtpA-5e04A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		3 / 3 TRP A 232
ARG A 235
LEU A 240
 None
 0.96A 5dbyA-5e04A:
undetectable		 5dbyA-5e04A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		4 / 6 ASP A 376
TYR A 383
PHE A 246
TYR A 264
 None
 1.37A 5e2iA-5e04A:
undetectable		 5e2iA-5e04A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5e04 NUCLEOPROTEIN
(Andes
orthohantavirus) 		3 / 3 VAL A 272
TYR A 320
GLU A 326
 None
 0.96A 5zmqD-5e04A:
undetectable
5zmqE-5e04A:
undetectable		 5zmqD-5e04A:
18.75
5zmqE-5e04A:
14.62