SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		5 / 12 LEU A 177
LEU A 127
GLY A 123
TRP A 119
LEU A 138
 None
 1.37A 2w8yA-5e05A:
undetectable		 2w8yA-5e05A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		4 / 5 ILE A 373
TYR A 364
ARG A 367
THR A 200
 None
 1.33A 3abkN-5e05A:
undetectable
3abkW-5e05A:
undetectable		 3abkN-5e05A:
20.72
3abkW-5e05A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		3 / 3 CYH A 203
PRO A 316
ASP A 312
 None
 0.98A 3hlwB-5e05A:
undetectable		 3hlwB-5e05A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		3 / 3 HIS A 394
PHE A 331
PHE A 330
 None
 0.37A 3lk0D-5e05A:
undetectable		 3lk0D-5e05A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		4 / 5 ILE A 280
PRO A 316
SER A 121
LYS A 120
 None
 0.71A 3tkdB-5e05A:
undetectable		 3tkdB-5e05A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		4 / 5 ILE A 280
PRO A 316
SER A 121
LYS A 120
 None
 0.73A 3tkdA-5e05A:
undetectable		 3tkdA-5e05A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		4 / 8 ILE A 236
ILE A 379
PHE A 330
GLY A 388
 None
 0.78A 4hdlA-5e05A:
undetectable		 4hdlA-5e05A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		3 / 3 PRO A 245
ASN A 261
HIS A 386
 None
 0.97A 4ma3H-5e05A:
undetectable
4ma3L-5e05A:
undetectable		 4ma3H-5e05A:
22.56
4ma3L-5e05A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		4 / 4 PRO A 301
MET A 324
GLY A 328
VAL A 306
 None
 0.93A 6ak3A-5e05A:
undetectable		 6ak3A-5e05A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5e05 NUCLEOCAPSID PROTEIN
(Sin
Nombre
orthohantavirus) 		3 / 3 SER A 163
SER A 164
ALA A 137
 None
 0.73A 6dwnC-5e05A:
undetectable		 6dwnC-5e05A:
15.16