SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 12 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 501 (-3.5A)
None
None
 1.04A 1r30A-5e0eA:
undetectable		 1r30A-5e0eA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 12 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 501 (-3.5A)
None
None
 1.04A 1r30B-5e0eA:
undetectable		 1r30B-5e0eA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		3 / 3 ASP A 266
GLU A 250
TYR A 244
 None
 0.81A 1wsvA-5e0eA:
undetectable		 1wsvA-5e0eA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 11 ARG A  98
ALA A 298
THR A 302
VAL A 367
PRO A 368
 HEM  A 501 (-2.7A)
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
None
 0.77A 2nnhA-5e0eA:
52.2		 2nnhA-5e0eA:
52.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 7 SER A 160
PHE A 157
ILE A 453
PHE A 171
 None
 1.14A 2q6hA-5e0eA:
undetectable		 2q6hA-5e0eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 7 SER A 160
PHE A 157
ILE A 453
PHE A 171
 None
 1.13A 2qb4A-5e0eA:
undetectable		 2qb4A-5e0eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 6 SER A 160
PHE A 157
ILE A 453
PHE A 171
 None
 1.12A 2qeiA-5e0eA:
undetectable		 2qeiA-5e0eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 TYR A 401
ARG A  85
GLN A 400
ARG A  59
 None
 1.14A 2vxaA-5e0eA:
undetectable
2vxaC-5e0eA:
undetectable
2vxaE-5e0eA:
undetectable		 2vxaA-5e0eA:
9.19
2vxaC-5e0eA:
9.19
2vxaE-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 GLN A 400
TYR A 401
ARG A  85
ARG A  59
 None
 1.13A 2vxaA-5e0eA:
undetectable
2vxaB-5e0eA:
undetectable
2vxaK-5e0eA:
undetectable		 2vxaA-5e0eA:
9.19
2vxaB-5e0eA:
9.19
2vxaK-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 GLN A 400
TYR A 401
ARG A  85
ARG A  59
 None
 1.15A 2vxaB-5e0eA:
undetectable
2vxaC-5e0eA:
undetectable
2vxaG-5e0eA:
undetectable		 2vxaB-5e0eA:
9.19
2vxaC-5e0eA:
9.19
2vxaG-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 TYR A 401
ARG A  85
GLN A 400
ARG A  59
 None
 1.15A 2vxaD-5e0eA:
undetectable
2vxaF-5e0eA:
undetectable
2vxaI-5e0eA:
undetectable		 2vxaD-5e0eA:
9.19
2vxaF-5e0eA:
9.19
2vxaI-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 GLN A 400
TYR A 401
ARG A  85
ARG A  59
 None
 1.15A 2vxaD-5e0eA:
undetectable
2vxaE-5e0eA:
undetectable
2vxaL-5e0eA:
undetectable		 2vxaD-5e0eA:
9.19
2vxaE-5e0eA:
9.19
2vxaL-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 ARG A  59
TYR A 401
ARG A  85
GLN A 400
 None
 1.14A 2vxaF-5e0eA:
undetectable
2vxaG-5e0eA:
undetectable
2vxaI-5e0eA:
undetectable		 2vxaF-5e0eA:
9.19
2vxaG-5e0eA:
9.19
2vxaI-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 ARG A  59
GLN A 400
TYR A 401
ARG A  85
 None
 1.14A 2vxaB-5e0eA:
undetectable
2vxaG-5e0eA:
undetectable
2vxaH-5e0eA:
undetectable		 2vxaB-5e0eA:
9.19
2vxaG-5e0eA:
9.19
2vxaH-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 GLN A 400
TYR A 401
ARG A  85
ARG A  59
 None
 1.11A 2vxaH-5e0eA:
undetectable
2vxaI-5e0eA:
undetectable
2vxaJ-5e0eA:
undetectable		 2vxaH-5e0eA:
9.19
2vxaI-5e0eA:
9.19
2vxaJ-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 ARG A  59
TYR A 401
ARG A  85
GLN A 400
 None
 1.13A 2vxaD-5e0eA:
undetectable
2vxaJ-5e0eA:
undetectable
2vxaL-5e0eA:
undetectable		 2vxaD-5e0eA:
9.19
2vxaJ-5e0eA:
9.19
2vxaL-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 ARG A  59
GLN A 400
TYR A 401
ARG A  85
 None
 1.14A 2vxaH-5e0eA:
undetectable
2vxaJ-5e0eA:
undetectable
2vxaK-5e0eA:
undetectable		 2vxaH-5e0eA:
9.19
2vxaJ-5e0eA:
9.19
2vxaK-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 ARG A  59
GLN A 400
TYR A 401
ARG A  85
 None
 1.15A 2vxaA-5e0eA:
undetectable
2vxaK-5e0eA:
undetectable
2vxaL-5e0eA:
undetectable		 2vxaA-5e0eA:
9.19
2vxaK-5e0eA:
9.19
2vxaL-5e0eA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		3 / 3 ARG A 187
GLU A 148
SER A 248
 None
 0.66A 2xctD-5e0eA:
undetectable		 2xctD-5e0eA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 12 ILE A 178
ASN A 444
GLY A 438
GLY A 440
LEU A 295
 None
None
HEM  A 501 (-3.8A)
None
None
 1.19A 2zw9A-5e0eA:
undetectable		 2zw9A-5e0eA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 7 VAL A 324
TYR A 348
GLU A 355
PRO A 410
 None
 1.21A 3hs4A-5e0eA:
undetectable		 3hs4A-5e0eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 9 PHE A 171
GLY A 299
ILE A 146
PHE A 450
PHE A 311
 None
HEM  A 501 (-3.5A)
None
None
None
 1.47A 3ko0A-5e0eA:
undetectable
3ko0C-5e0eA:
undetectable		 3ko0A-5e0eA:
11.40
3ko0C-5e0eA:
11.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		7 / 11 ILE A 209
PHE A 297
ALA A 298
GLU A 301
THR A 302
ILE A 363
VAL A 367
 None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
HEM  A 501 ( 4.4A)
 0.88A 3kw4A-5e0eA:
54.6		 3kw4A-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		7 / 11 ILE A 209
SER A 210
PHE A 297
ALA A 298
GLU A 301
THR A 302
VAL A 367
 None
None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 1.03A 3kw4A-5e0eA:
54.6		 3kw4A-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 10 ILE A 209
PHE A 297
ALA A 298
THR A 302
ILE A 363
VAL A 367
 None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
HEM  A 501 ( 4.4A)
 1.08A 3me6A-5e0eA:
53.7		 3me6A-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		7 / 10 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
ILE A 363
VAL A 367
 None
None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
HEM  A 501 ( 4.4A)
 1.00A 3me6A-5e0eA:
53.7		 3me6A-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 9 VAL A 104
PHE A 108
ILE A 209
ALA A 298
VAL A 367
 None
None
None
HEM  A 501 ( 3.1A)
HEM  A 501 ( 4.4A)
 1.02A 3me6C-5e0eA:
53.6		 3me6C-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 9 VAL A 104
PHE A 108
ILE A 209
THR A 302
VAL A 367
 None
None
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 0.80A 3me6C-5e0eA:
53.6		 3me6C-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 9 ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
 None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 1.10A 3me6D-5e0eA:
53.8		 3me6D-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 9 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
 None
None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 0.82A 3me6D-5e0eA:
53.8		 3me6D-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 10 PHE A 108
VAL A 114
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
HEM  A 501 (-3.5A)
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 0.83A 3t3qA-5e0eA:
51.7		 3t3qA-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 10 PHE A 115
PHE A 297
ALA A 298
THR A 302
ILE A 363
 None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 1.10A 3t3qA-5e0eA:
51.7		 3t3qA-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 10 PHE A 108
VAL A 114
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
HEM  A 501 (-3.5A)
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 0.90A 3t3qB-5e0eA:
51.7		 3t3qB-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 10 PHE A 115
PHE A 297
ALA A 298
THR A 302
ILE A 363
 None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 1.20A 3t3qB-5e0eA:
51.7		 3t3qB-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 10 PHE A 108
VAL A 114
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
HEM  A 501 (-3.5A)
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 0.90A 3t3qC-5e0eA:
51.7		 3t3qC-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 10 PHE A 115
PHE A 297
ALA A 298
THR A 302
ILE A 363
 None
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 1.18A 3t3qC-5e0eA:
51.7		 3t3qC-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 10 PHE A 108
VAL A 114
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
HEM  A 501 (-3.5A)
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
 0.93A 3t3qD-5e0eA:
51.8		 3t3qD-5e0eA:
56.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 11 PHE A 108
VAL A 114
PHE A 115
GLY A 299
THR A 302
 None
HEM  A 501 (-3.5A)
None
HEM  A 501 (-3.5A)
CPZ  A 502 ( 4.0A)
 0.93A 3t3rA-5e0eA:
51.5		 3t3rA-5e0eA:
55.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 10 PHE A 297
VAL A 114
PHE A 115
PHE A 206
GLY A 299
 None
HEM  A 501 (-3.5A)
None
None
HEM  A 501 (-3.5A)
 1.26A 3t3rD-5e0eA:
51.6		 3t3rD-5e0eA:
55.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		7 / 11 ILE A 101
PHE A 108
PHE A 206
ILE A 209
ALA A 298
GLU A 301
THR A 302
 CPZ  A 502 (-4.7A)
None
None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
 1.24A 3tmzA-5e0eA:
55.8		 3tmzA-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		8 / 11 ILE A 101
PHE A 206
ILE A 209
ALA A 298
GLU A 301
THR A 302
VAL A 367
PRO A 368
 CPZ  A 502 (-4.7A)
None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
None
 0.87A 3tmzA-5e0eA:
55.8		 3tmzA-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 11 PHE A 115
ILE A 209
ALA A 298
GLU A 301
THR A 302
VAL A 367
 None
None
HEM  A 501 ( 3.1A)
None
CPZ  A 502 ( 4.0A)
HEM  A 501 ( 4.4A)
 0.88A 3tmzA-5e0eA:
55.8		 3tmzA-5e0eA:
79.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		6 / 11 ILE A 101
LEU A 238
ALA A 298
THR A 302
ILE A 363
VAL A 367
 CPZ  A 502 (-4.7A)
None
HEM  A 501 ( 3.1A)
CPZ  A 502 ( 4.0A)
HEM  A 501 (-4.1A)
HEM  A 501 ( 4.4A)
 0.66A 4h1nA-5e0eA:
53.7		 4h1nA-5e0eA:
79.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 8 ILE A 101
GLU A 218
ALA A 298
VAL A 367
PRO A 368
 CPZ  A 502 (-4.7A)
None
HEM  A 501 ( 3.1A)
HEM  A 501 ( 4.4A)
None
 1.09A 4jltA-5e0eA:
54.7		 4jltA-5e0eA:
79.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 7 TYR A  79
ILE A  84
GLY A 366
LEU A  52
 None
 0.90A 4ze3A-5e0eA:
29.9		 4ze3A-5e0eA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 6 ILE A 453
PHE A 157
ARG A 308
THR A 175
 None
 1.04A 5b1aN-5e0eA:
undetectable
5b1aW-5e0eA:
undetectable		 5b1aN-5e0eA:
21.92
5b1aW-5e0eA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		5 / 12 ILE A 182
GLY A 438
ILE A 245
THR A 300
LEU A 198
 None
HEM  A 501 (-3.8A)
None
None
None
 1.03A 5e72A-5e0eA:
undetectable		 5e72A-5e0eA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 TYR A  79
ILE A  84
GLY A 366
LEU A  52
 None
 0.82A 5hs1A-5e0eA:
30.4		 5hs1A-5e0eA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 6 GLN A 172
PHE A 206
CYH A 180
PHE A 188
 None
 1.43A 5mwyA-5e0eA:
2.4		 5mwyA-5e0eA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 7 THR A 386
VAL A  76
HIS A  69
PRO A  74
 None
 1.16A 5vkqA-5e0eA:
undetectable
5vkqB-5e0eA:
undetectable		 5vkqA-5e0eA:
13.56
5vkqB-5e0eA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 8 THR A 386
VAL A  76
HIS A  69
PRO A  74
 None
 1.16A 5vkqB-5e0eA:
undetectable
5vkqC-5e0eA:
undetectable		 5vkqB-5e0eA:
13.56
5vkqC-5e0eA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 7 THR A 386
VAL A  76
HIS A  69
PRO A  74
 None
 1.14A 5vkqC-5e0eA:
undetectable
5vkqD-5e0eA:
undetectable		 5vkqC-5e0eA:
13.56
5vkqD-5e0eA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B
(Neotoma
lepida) 		4 / 5 ILE A 453
PHE A 157
ARG A 308
THR A 175
 None
 1.13A 5z84N-5e0eA:
1.5
5z84W-5e0eA:
undetectable		 5z84N-5e0eA:
21.92
5z84W-5e0eA:
8.98