SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU X  57
VAL X  20
LEU X 105
ASP X  49
 None
 0.86A 3cs9D-5e0nX:
undetectable		 3cs9D-5e0nX:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE X  64
ALA X 125
LEU X  43
MET X  36
 None
 0.98A 3l4dD-5e0nX:
undetectable		 3l4dD-5e0nX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL X  98
LEU X 122
GLY X 154
SER X 151
LEU X  95
 None
 1.05A 3n8zA-5e0nX:
undetectable		 3n8zA-5e0nX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU X 126
ARG X 131
ILE X 186
ARG X 167
 None
 1.27A 3ticA-5e0nX:
undetectable		 3ticA-5e0nX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY X 115
GLY X  63
MET X  28
ASN X  29
 None
 1.20A 4fglC-5e0nX:
undetectable		 4fglC-5e0nX:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE X 132
THR X 192
VAL X 109
PHE X 139
 None
 1.27A 4iarA-5e0nX:
undetectable		 4iarA-5e0nX:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 MET X  36
LEU X  39
LEU X 155
LEU X  95
ALA X 125
 None
 1.34A 4m11A-5e0nX:
undetectable		 4m11A-5e0nX:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU X  39
GLY X 119
GLY X 121
LEU X  22
GLY X 154
 None
 0.94A 4n09C-5e0nX:
undetectable		 4n09C-5e0nX:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 LEU X 126
ALA X 162
ILE X 163
SER X 190
ALA X 117
 None
 1.25A 4wboB-5e0nX:
undetectable		 4wboB-5e0nX:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5e0n ENOYL-COA
HYDRATASE/ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS X 221
ARG X  53
VAL X  52
 None
 1.05A 4x3uA-5e0nX:
undetectable
4x3uB-5e0nX:
undetectable		 4x3uA-5e0nX:
11.81
4x3uB-5e0nX:
11.81