SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		5 / 12 GLY B 800
ARG A  74
THR B 729
ILE B 753
PHE B 751
 None
 1.10A 1m2zD-5e0qB:
undetectable		 1m2zD-5e0qB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		5 / 7 ILE B 721
GLY B 719
ASN A  33
ASN B 771
ARG A 114
 None
 1.29A 1oniG-5e0qB:
undetectable
1oniI-5e0qB:
undetectable		 1oniG-5e0qB:
21.25
1oniI-5e0qB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		4 / 7 ASP B 775
SER B 776
SER A  57
ASN A  54
 None
 1.07A 2cmlA-5e0qB:
undetectable		 2cmlA-5e0qB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		4 / 8 ASP B 775
SER B 776
SER A  57
ASN A  54
 None
 0.90A 2cmlB-5e0qB:
undetectable		 2cmlB-5e0qB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		4 / 8 ASP B 775
SER B 776
SER A  57
ASN A  54
 None
 1.12A 2cmlC-5e0qB:
undetectable		 2cmlC-5e0qB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		4 / 8 ASP B 775
SER B 776
SER A  57
ASN A  54
 None
 0.99A 2cmlD-5e0qB:
undetectable		 2cmlD-5e0qB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		3 / 3 ASN B 771
TYR A 115
SER A 105
 None
 0.94A 2gvcB-5e0qB:
undetectable		 2gvcB-5e0qB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		3 / 3 ASN B 771
TYR A 115
SER A 105
 None
 0.94A 2gvcE-5e0qB:
undetectable		 2gvcE-5e0qB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		4 / 8 VAL B 767
ILE B 753
VAL B 778
VAL B 787
 None
 0.78A 3fi0B-5e0qB:
undetectable		 3fi0B-5e0qB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		4 / 8 VAL B 767
ILE B 753
VAL B 778
VAL B 787
 None
 0.75A 3fi0G-5e0qB:
undetectable		 3fi0G-5e0qB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		4 / 8 VAL B 767
ILE B 753
VAL B 778
VAL B 787
 None
 0.74A 3fi0Q-5e0qB:
undetectable		 3fi0Q-5e0qB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		5 / 12 HIS B 779
ASP B 775
LEU B 774
ILE B 761
THR B 723
 None
 1.18A 3nrrB-5e0qB:
undetectable		 3nrrB-5e0qB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		4 / 7 ASP B 810
THR B 808
ARG B 853
SER B 856
 None
 1.48A 4o4dA-5e0qB:
undetectable		 4o4dA-5e0qB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		4 / 7 ILE B 777
THR B 729
ILE B 753
LEU B 772
 None
 0.83A 5fukA-5e0qB:
undetectable
5fukB-5e0qB:
undetectable		 5fukA-5e0qB:
19.67
5fukB-5e0qB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Xenopus
tropicalis) 		5 / 12 SER B 856
GLY B 759
GLY B 757
VAL B 785
LEU B 809
 None
 1.20A 5kocB-5e0qB:
undetectable		 5kocB-5e0qB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		5 / 12 SER A  56
ASN A  33
ARG A  29
THR B 729
GLU B 745
 None
 1.29A 5v1tA-5e0qA:
undetectable		 5v1tA-5e0qA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96
(Vicugna
pacos;
Xenopus
tropicalis) 		5 / 9 ASP B 775
SER B 776
GLY A 104
ASN A  54
VAL A  35
 None
 1.28A 6giqA-5e0qB:
undetectable
6giqE-5e0qB:
undetectable
6giqI-5e0qB:
undetectable		 6giqA-5e0qB:
16.14
6giqE-5e0qB:
18.58
6giqI-5e0qB:
17.22