SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 10 LEU A  80
ASP A  67
ALA A  70
ASP A  91
ILE A  72
 None
None
None
SAH  A 301 (-2.7A)
None
 1.09A 1d4sA-5e1bA:
undetectable		 1d4sA-5e1bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		3 / 3 PHE A 122
TYR A 129
PRO A 124
 None
 0.71A 1mcnA-5e1bA:
undetectable
1mcnB-5e1bA:
undetectable
1mcnP-5e1bA:
undetectable		 1mcnA-5e1bA:
18.04
1mcnB-5e1bA:
18.04
1mcnP-5e1bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ASP A  91
THR A  93
HIS A 140
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.8A)
 0.89A 2gluA-5e1bA:
17.7		 2gluA-5e1bA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 11 LEU A  80
ASP A  67
ALA A  70
ASP A  91
ILE A  72
 None
None
None
SAH  A 301 (-2.7A)
None
 1.08A 2o4pA-5e1bA:
undetectable		 2o4pA-5e1bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		4 / 7 TYR A  13
SER A  14
ILE A  92
SER A 181
 None
None
SAH  A 301 (-3.9A)
None
 1.18A 2xz5A-5e1bA:
undetectable
2xz5B-5e1bA:
undetectable		 2xz5A-5e1bA:
23.05
2xz5B-5e1bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 ASP A  67
GLY A  69
ASP A  91
ILE A  92
LEU A 141
 None
SAH  A 301 (-3.9A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
None
 0.94A 3cjtC-5e1bA:
13.0		 3cjtC-5e1bA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 LEU A  80
ASP A  67
ALA A  70
ASP A  91
VAL A  27
 None
None
None
SAH  A 301 (-2.7A)
None
 0.96A 3cyxA-5e1bA:
undetectable		 3cyxA-5e1bA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  71
ASP A  91
ILE A  92
GLY A 118
GLN A 120
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
 0.58A 3eeyJ-5e1bA:
10.5		 3eeyJ-5e1bA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 SER A  38
LEU A  49
SER A  45
PHE A  48
ASP A  67
 None
 1.11A 3ko0G-5e1bA:
undetectable
3ko0H-5e1bA:
undetectable
3ko0I-5e1bA:
undetectable
3ko0J-5e1bA:
undetectable		 3ko0G-5e1bA:
20.08
3ko0H-5e1bA:
20.08
3ko0I-5e1bA:
20.08
3ko0J-5e1bA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 11 SER A  38
ASP A  67
LEU A  49
SER A  45
PHE A  48
 None
 1.20A 3ko0Q-5e1bA:
undetectable
3ko0R-5e1bA:
undetectable
3ko0S-5e1bA:
undetectable
3ko0T-5e1bA:
undetectable		 3ko0Q-5e1bA:
20.08
3ko0R-5e1bA:
20.08
3ko0S-5e1bA:
20.08
3ko0T-5e1bA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 10 LEU A  80
ASP A  67
ALA A  70
ASP A  91
VAL A  27
 None
None
None
SAH  A 301 (-2.7A)
None
 0.94A 3oxwA-5e1bA:
undetectable		 3oxwA-5e1bA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 10 LEU A  80
ASP A  67
ALA A  70
ASP A  91
ILE A  72
 None
None
None
SAH  A 301 (-2.7A)
None
 1.01A 3oxwC-5e1bA:
undetectable		 3oxwC-5e1bA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 10 LEU A  80
ASP A  67
ALA A  70
ASP A  91
VAL A  27
 None
None
None
SAH  A 301 (-2.7A)
None
 0.95A 3oxwC-5e1bA:
undetectable		 3oxwC-5e1bA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 LEU A  80
ASP A  67
ALA A  70
ASP A  91
VAL A  27
 None
None
None
SAH  A 301 (-2.7A)
None
 1.04A 3oxxC-5e1bA:
undetectable		 3oxxC-5e1bA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  92
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
None
 0.61A 3uj7B-5e1bA:
18.4		 3uj7B-5e1bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 11 ASP A  67
GLY A  69
GLY A  71
ILE A  75
ASP A  91
 None
SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
None
SAH  A 301 (-2.7A)
 0.43A 4dcmA-5e1bA:
13.1		 4dcmA-5e1bA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  92
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
None
 0.50A 4iv0A-5e1bA:
18.5		 4iv0A-5e1bA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		6 / 12 GLY A  69
GLY A  71
ASP A  91
ILE A  92
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
None
 0.43A 4iv8A-5e1bA:
17.5		 4iv8A-5e1bA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		6 / 12 GLY A  69
GLY A  71
ASP A  91
ILE A  92
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
None
 0.39A 4iv8B-5e1bA:
17.6		 4iv8B-5e1bA:
31.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  92
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
None
 0.56A 4mwzA-5e1bA:
18.0		 4mwzA-5e1bA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  92
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
None
 0.57A 4mwzB-5e1bA:
18.4		 4mwzB-5e1bA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 LEU A  80
ASP A  67
ALA A  70
ASP A  91
ILE A  72
 None
None
None
SAH  A 301 (-2.7A)
None
 1.06A 4njuC-5e1bA:
undetectable		 4njuC-5e1bA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  92
LEU A 119
VAL A 137
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 4.4A)
 0.90A 4qdjA-5e1bA:
17.0		 4qdjA-5e1bA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  92
VAL A 137
HIS A 140
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.8A)
 0.97A 4qdjA-5e1bA:
17.0		 4qdjA-5e1bA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		4 / 6 ASP A 127
ARG A 158
LEU A 157
ASP A 130
 None
UNX  A 321 ( 3.9A)
None
None
 1.07A 5tdzA-5e1bA:
undetectable		 5tdzA-5e1bA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		8 / 12 MET A  30
GLY A  69
LEU A 119
GLN A 135
TRP A 136
VAL A 137
HIS A 140
LEU A 141
 SAH  A 301 (-4.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
None
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.8A)
None
 0.33A 5ubbA-5e1bA:
36.2		 5ubbA-5e1bA:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		4 / 5 GLY A  71
ARG A  74
ASP A  91
GLN A 120
 SAH  A 301 (-3.1A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.4A)
 0.21A 5ubbA-5e1bA:
36.2		 5ubbA-5e1bA:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ASP A  91
HIS A 140
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
None
 0.70A 5wy0A-5e1bA:
13.0		 5wy0A-5e1bA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ASP A  91
ILE A  92
LEU A 141
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
None
 0.74A 5wy0A-5e1bA:
13.0		 5wy0A-5e1bA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1
(Homo
sapiens) 		4 / 4 PHE A  48
LEU A 157
LEU A 202
VAL A 131
 None
 1.26A 5xxiA-5e1bA:
undetectable		 5xxiA-5e1bA:
20.34