SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5e1t TNF
RECEPTOR-ASSOCIATED
FACTOR 1
(Homo
sapiens) 		4 / 7 HIS A 321
ASP A 360
THR A 316
GLY A 317
 None
 1.05A 2f6dA-5e1tA:
undetectable		 2f6dA-5e1tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5e1t TNF
RECEPTOR-ASSOCIATED
FACTOR 1
(Homo
sapiens) 		3 / 3 LEU A 270
MET A 348
ASP A 351
 None
 0.92A 3v5wA-5e1tA:
undetectable		 3v5wA-5e1tA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5e1t TNF
RECEPTOR-ASSOCIATED
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 291
LEU A 309
LEU A 322
ILE A 273
PHE A 388
 None
 0.89A 4a7aB-5e1tA:
undetectable		 4a7aB-5e1tA:
17.03