SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ILE B 198
ALA B  38
PHE B 191
GLN B 235
LEU B 180
 None
 1.19A 1dlsA-5e1vB:
undetectable		 1dlsA-5e1vB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 11 PHE B 274
SER B 276
LEU B 221
ILE B  64
VAL B 203
 None
 1.36A 3a9eB-5e1vB:
undetectable		 3a9eB-5e1vB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 PHE B 193
GLY B  36
LEU B  37
CYH B  54
LEU B 233
 None
 0.93A 3av6A-5e1vB:
undetectable		 3av6A-5e1vB:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 10 LEU B 176
GLY B 173
VAL B 141
LEU B 209
ILE B 167
 None
 0.85A 3em3A-5e1vB:
undetectable		 3em3A-5e1vB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ILE B  43
ILE B  64
LEU B  68
LEU B  78
ILE B  42
 None
 1.03A 4m2xC-5e1vB:
undetectable		 4m2xC-5e1vB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ILE B  43
ILE B  64
LEU B  68
LEU B  78
ILE B  42
 None
 0.98A 4m2xE-5e1vB:
undetectable		 4m2xE-5e1vB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.91A 4o2bD-5e1vB:
undetectable		 4o2bD-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.96A 5eypB-5e1vB:
undetectable		 5eypB-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.94A 5nm5B-5e1vB:
undetectable		 5nm5B-5e1vB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 1.01A 5xiwB-5e1vB:
undetectable		 5xiwB-5e1vB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 LEU B  62
ALA B  94
ILE B  92
ALA B 114
ILE B  80
 None
 0.92A 5xiwD-5e1vB:
undetectable		 5xiwD-5e1vB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLU B 259
ASN B 262
ALA B 269
ALA B 230
PHE B 228
 None
 1.06A 5zw4A-5e1vB:
undetectable		 5zw4A-5e1vB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5e1v POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 11 ASP B  41
ILE B 198
LEU B 271
ILE B  92
MET B 116
 None
 1.45A 6fgcA-5e1vB:
undetectable		 6fgcA-5e1vB:
14.61