SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e24'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		4 / 7 ILE E 177
GLY E 178
PRO E 145
ASN E 231
 None
 0.74A 1oniG-5e24E:
undetectable
1oniI-5e24E:
undetectable		 1oniG-5e24E:
14.95
1oniI-5e24E:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 12 LEU E 253
ALA E 293
ALA E 262
VAL E 129
LEU E 357
 None
EDO  E 617 (-4.6A)
None
None
EDO  E 618 ( 4.3A)
 1.13A 1rbpA-5e24E:
undetectable		 1rbpA-5e24E:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 12 ALA E 199
GLN E 187
ILE E 177
PHE E 213
GLN E 184
 None
 1.08A 1uduB-5e24E:
undetectable		 1uduB-5e24E:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 11 LEU E 336
PHE E 362
LEU E 333
VAL E 279
VAL E 261
 None
 1.37A 2po5B-5e24E:
undetectable		 2po5B-5e24E:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 11 GLN E 457
ILE E 500
ALA E 465
PHE E 460
LEU E 445
 None
 1.19A 2qjuA-5e24E:
undetectable		 2qjuA-5e24E:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		4 / 6 ILE E 122
TYR E 113
LEU E 149
PHE E 150
 None
None
EDO  E 610 (-4.9A)
EDO  E 603 (-3.7A)
 0.88A 3adsA-5e24E:
undetectable		 3adsA-5e24E:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 LYS E 132
LYS E 211
VAL E 237
 None
 0.99A 3brfA-5e24E:
44.6		 3brfA-5e24E:
55.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 9 ILE E 147
GLY E 178
ILE E 179
PRO E 145
ILE E 124
 None
 0.98A 3nu4A-5e24E:
undetectable		 3nu4A-5e24E:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 ALA E 127
VAL E 129
GLN E 356
 None
None
EDO  E 614 (-4.1A)
 0.69A 3of4B-5e24E:
undetectable		 3of4B-5e24E:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 9 ILE E 147
GLY E 178
ILE E 179
PRO E 145
ILE E 124
 None
 0.98A 3s45A-5e24E:
undetectable		 3s45A-5e24E:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 TYR E 363
MET E 364
ILE E 380
 None
EDO  E 612 (-4.9A)
None
 0.92A 4c8bB-5e24E:
undetectable		 4c8bB-5e24E:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 TYR E 134
ARG E 139
SER E 133
 None
 1.17A 4dr2I-5e24E:
undetectable
4dr2J-5e24E:
undetectable		 4dr2I-5e24E:
17.22
4dr2J-5e24E:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 TYR E 518
ARG E 486
SER E 483
 None
 1.14A 4dr2I-5e24E:
undetectable
4dr2J-5e24E:
undetectable		 4dr2I-5e24E:
17.22
4dr2J-5e24E:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		4 / 8 MET E 219
ILE E 124
PRO E 424
VAL E 428
 None
None
EDO  E 616 (-4.5A)
None
 1.29A 4f4dB-5e24E:
undetectable		 4f4dB-5e24E:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 TYR E 518
ARG E 486
SER E 483
 None
 1.01A 4khpI-5e24E:
undetectable
4khpJ-5e24E:
undetectable		 4khpI-5e24E:
15.99
4khpJ-5e24E:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 MET E 110
ASP E 119
PHE E 414
 None
 1.06A 4xeyA-5e24E:
undetectable		 4xeyA-5e24E:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		3 / 3 MET E 110
ASP E 119
PHE E 414
 None
 1.02A 4xeyB-5e24E:
undetectable		 4xeyB-5e24E:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		5 / 12 LEU E 125
LEU E 215
ALA E 262
ALA E 198
LEU E 189
 EDO  E 604 (-4.9A)
None
None
EDO  E 623 ( 3.9A)
None
 1.03A 5jw1B-5e24E:
undetectable		 5jw1B-5e24E:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5e24 SUPPRESSOR OF
HAIRLESS PROTEIN
(Drosophila
melanogaster) 		4 / 8 GLY E 151
VAL E 121
ASP E 119
TYR E 415
 EDO  E 610 (-4.8A)
None
None
None
 0.93A 5vlmA-5e24E:
undetectable		 5vlmA-5e24E:
18.34