SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 6 LEU A  28
ILE A  93
ARG A  91
VAL A  20
 None
None
AKG  A 302 ( 4.1A)
None
 0.94A 1db1A-5e25A:
undetectable		 1db1A-5e25A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.20A 1jhoA-5e25A:
undetectable		 1jhoA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.23A 1jhrA-5e25A:
undetectable		 1jhrA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.22A 1jhyA-5e25A:
undetectable		 1jhyA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.22A 1l4nA-5e25A:
undetectable		 1l4nA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.21A 1l5kA-5e25A:
undetectable		 1l5kA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.23A 1l5lA-5e25A:
undetectable		 1l5lA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.22A 1l5mA-5e25A:
undetectable		 1l5mA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 12 TYR A 238
LEU A 237
GLY A 266
GLY A 264
ILE A 243
 None
 1.04A 1p91B-5e25A:
undetectable		 1p91B-5e25A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 8 ARG A  91
GLY A 247
THR A 248
ALA A 249
 AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
 0.51A 2a1hA-5e25A:
28.7
2a1hB-5e25A:
28.7		 2a1hA-5e25A:
25.54
2a1hB-5e25A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 8 TYR A  89
ARG A  91
GLY A 247
THR A 248
 AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
 0.41A 2a1hA-5e25A:
28.7
2a1hB-5e25A:
28.7		 2a1hA-5e25A:
25.54
2a1hB-5e25A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 10 TYR A  89
ARG A  91
GLY A 247
THR A 248
ALA A 249
 AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
 0.48A 2coiA-5e25A:
29.3
2coiB-5e25A:
29.6		 2coiA-5e25A:
24.56
2coiB-5e25A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 10 TYR A  89
ARG A  91
GLY A 247
THR A 248
ALA A 249
 AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
 0.43A 2coiA-5e25A:
29.3
2coiB-5e25A:
29.6		 2coiA-5e25A:
24.56
2coiB-5e25A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		6 / 11 PHE A  34
TYR A  89
ARG A  91
GLY A 247
THR A 248
ALA A 249
 AKG  A 302 (-4.9A)
AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
 0.54A 2cojA-5e25A:
29.2
2cojB-5e25A:
29.6		 2cojA-5e25A:
24.56
2cojB-5e25A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 TYR A  89
ARG A  91
GLY A 247
THR A 248
ALA A 249
 AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
 0.51A 2cojA-5e25A:
29.2
2cojB-5e25A:
29.6		 2cojA-5e25A:
24.56
2cojB-5e25A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		7 / 8 TYR A  89
ARG A  91
GLY A 188
GLY A 247
THR A 248
ALA A 249
ALA A 250
 AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 ( 4.0A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
None
 0.31A 2ej3A-5e25A:
38.8		 2ej3A-5e25A:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		9 / 10 PHE A  34
TYR A  89
ARG A  91
TYR A 156
GLY A 188
GLY A 247
THR A 248
ALA A 249
ALA A 250
 AKG  A 302 (-4.9A)
AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-4.3A)
PLP  A 301 ( 4.0A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
None
 0.39A 2ej3B-5e25A:
38.7		 2ej3B-5e25A:
41.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 12 ARG A 140
GLY A 186
ILE A 243
ILE A 135
ILE A 183
 None
 0.87A 2hs1B-5e25A:
undetectable		 2hs1B-5e25A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 12 ARG A 140
GLY A 186
ILE A 243
ILE A 135
ILE A 183
 None
 0.92A 2o4sB-5e25A:
undetectable		 2o4sB-5e25A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 10 LEU A 127
ASP A 172
ILE A 258
VAL A 255
LEU A 132
 None
 1.20A 3ogpB-5e25A:
undetectable		 3ogpB-5e25A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 10 LEU A 127
ILE A 258
VAL A 255
GLY A 186
LEU A 132
 None
 0.90A 3ogpB-5e25A:
undetectable		 3ogpB-5e25A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 10 LEU A 127
ILE A 258
VAL A 255
GLY A 186
LEU A 132
 None
 0.87A 3ogqA-5e25A:
undetectable		 3ogqA-5e25A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 12 ASP A 189
SER A 187
ASN A 159
ASN A 167
TYR A 124
 None
None
PLP  A 301 (-4.5A)
None
None
 1.46A 4dajA-5e25A:
undetectable		 4dajA-5e25A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 11 ILE A  65
ILE A  51
ALA A  73
ILE A 115
VAL A 113
 None
 0.93A 4h1nA-5e25A:
undetectable		 4h1nA-5e25A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		5 / 9 GLY A  99
PHE A  23
LEU A  28
SER A  21
GLY A  26
 None
 1.25A 4kqiA-5e25A:
undetectable		 4kqiA-5e25A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 6 GLU A 286
THR A 283
THR A 246
LEU A 219
 None
 1.13A 4pgfA-5e25A:
undetectable		 4pgfA-5e25A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 4 GLU A 286
THR A 283
THR A 246
LEU A 275
 None
 1.40A 5v96A-5e25A:
undetectable		 5v96A-5e25A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 4 GLU A 286
THR A 283
THR A 246
LEU A 275
 None
 1.40A 5v96B-5e25A:
undetectable		 5v96B-5e25A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 4 GLU A 286
THR A 283
THR A 246
LEU A 275
 None
 1.39A 5v96C-5e25A:
undetectable		 5v96C-5e25A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 4 GLU A 286
THR A 283
THR A 246
LEU A 275
 None
 1.38A 5v96D-5e25A:
undetectable		 5v96D-5e25A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5e25 BRANCHED-CHAIN
AMINOTRANSFERASE
(Geoglobus
acetivorans) 		4 / 5 LEU A 123
LEU A 132
THR A 246
ARG A 140
 None
 1.10A 6ew0F-5e25A:
undetectable		 6ew0F-5e25A:
16.01