SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 228
GLU A 269
LEU A 270
VAL A 352
 None
 1.06A 1hk1A-5e26A:
undetectable		 1hk1A-5e26A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 535
ASP A 539
GLY A 502
ILE A 501
 None
 0.84A 1t7iB-5e26A:
undetectable		 1t7iB-5e26A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 535
ASP A 539
GLY A 502
ILE A 501
 None
 0.84A 1t7jB-5e26A:
undetectable		 1t7jB-5e26A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 354
ASN A 355
HIS A 553
VAL A 266
 None
 1.15A 1wu8A-5e26A:
undetectable
1wu8C-5e26A:
undetectable		 1wu8A-5e26A:
21.96
1wu8C-5e26A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 564
SER A 351
LEU A 282
LEU A 275
 None
 1.05A 1yajA-5e26A:
1.0		 1yajA-5e26A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 564
SER A 351
LEU A 282
LEU A 275
 None
 1.03A 1yajD-5e26A:
2.6		 1yajD-5e26A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 538
LEU A 534
ILE A 495
ARG A 491
 None
 1.24A 2hc4A-5e26A:
undetectable		 2hc4A-5e26A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 393
SER A 395
ASN A 500
THR A 411
GLY A 410
 PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
None
None
PAU  A 602 (-3.3A)
 1.42A 2hmaA-5e26A:
undetectable		 2hmaA-5e26A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 346
ILE A 349
GLY A 558
ALA A 313
PHE A 214
 None
 0.77A 2yvlA-5e26A:
undetectable		 2yvlA-5e26A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 346
ILE A 349
GLY A 558
ALA A 313
PHE A 214
 None
 0.79A 2yvlB-5e26A:
undetectable		 2yvlB-5e26A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 346
ILE A 349
GLY A 558
ALA A 313
PHE A 214
 None
 0.78A 2yvlC-5e26A:
undetectable		 2yvlC-5e26A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 561
GLY A 558
LEU A 336
ILE A 349
LEU A 275
 None
 1.11A 2zbpA-5e26A:
undetectable		 2zbpA-5e26A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 MET A 298
GLY A 299
THR A 327
PHE A 295
PHE A 321
 None
 1.21A 3ag4A-5e26A:
undetectable
3ag4B-5e26A:
undetectable
3ag4T-5e26A:
undetectable		 3ag4A-5e26A:
20.53
3ag4B-5e26A:
19.84
3ag4T-5e26A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 535
ASP A 539
GLY A 502
ILE A 501
VAL A 518
 None
 1.09A 3ekvB-5e26A:
undetectable		 3ekvB-5e26A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 415
ALA A 490
ALA A 438
LEU A 524
LEU A 435
 ADP  A 601 (-3.5A)
None
None
None
None
 0.78A 3mteA-5e26A:
2.4		 3mteA-5e26A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 525
LEU A 222
THR A 261
 ADP  A 601 (-4.1A)
ADP  A 601 (-3.9A)
None
 0.87A 3oxcA-5e26A:
undetectable		 3oxcA-5e26A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 415
ALA A 490
ALA A 438
LEU A 524
LEU A 435
 ADP  A 601 (-3.5A)
None
None
None
None
 0.80A 3p2kA-5e26A:
2.3		 3p2kA-5e26A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 415
ALA A 490
ALA A 438
LEU A 524
LEU A 435
 ADP  A 601 (-3.5A)
None
None
None
None
 0.86A 3p2kC-5e26A:
2.8		 3p2kC-5e26A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 415
ALA A 490
ALA A 438
LEU A 524
LEU A 435
 ADP  A 601 (-3.5A)
None
None
None
None
 0.80A 3p2kD-5e26A:
undetectable		 3p2kD-5e26A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 346
GLY A 393
LEU A 339
ILE A 504
ILE A 501
 None
PAU  A 602 (-3.3A)
None
None
None
 1.10A 3pwwA-5e26A:
undetectable		 3pwwA-5e26A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 542
ARG A 506
LEU A 546
ASP A 539
 None
 1.42A 4ifxA-5e26A:
1.3		 4ifxA-5e26A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 542
ARG A 506
LEU A 546
ASP A 539
 None
 1.46A 4ig1A-5e26A:
undetectable		 4ig1A-5e26A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 405
LEU A 387
VAL A 520
LEU A 347
 None
 0.95A 4l1xA-5e26A:
undetectable		 4l1xA-5e26A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 535
ASP A 539
GLY A 502
ILE A 501
VAL A 518
 None
 1.11A 4q1wB-5e26A:
undetectable		 4q1wB-5e26A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 542
ARG A 506
LEU A 546
ASP A 539
 None
 1.47A 4xdtA-5e26A:
undetectable		 4xdtA-5e26A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 524
LEU A 435
ILE A 497
PHE A 418
 None
 1.04A 4y4dA-5e26A:
undetectable		 4y4dA-5e26A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 GLU A 338
GLY A 393
SER A 395
ARG A 407
GLY A 410
 PAU  A 602 (-2.7A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.3A)
 0.02A 5e26A-5e26A:
60.2
5e26B-5e26A:
55.8		 5e26A-5e26A:
100.00
5e26B-5e26A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 GLU A 338
GLY A 393
SER A 395
ARG A 407
GLY A 410
 PAU  A 602 (-2.7A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.3A)
 0.17A 5e26A-5e26A:
60.2
5e26B-5e26A:
55.8		 5e26A-5e26A:
100.00
5e26B-5e26A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 GLU A 338
GLY A 393
SER A 395
ARG A 407
GLY A 410
 PAU  A 602 (-2.7A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.3A)
 0.11A 5e26C-5e26A:
56.3
5e26D-5e26A:
56.0		 5e26C-5e26A:
100.00
5e26D-5e26A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 GLU A 338
GLY A 393
SER A 395
ARG A 407
GLY A 410
 PAU  A 602 (-2.7A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.3A)
 0.12A 5e26C-5e26A:
56.3
5e26D-5e26A:
56.0		 5e26C-5e26A:
100.00
5e26D-5e26A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 GLU A 338
GLY A 393
SER A 395
ARG A 407
GLY A 410
 PAU  A 602 (-2.7A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.1A)
PAU  A 602 (-3.3A)
PAU  A 602 (-3.3A)
 0.30A 5kprA-5e26A:
51.4		 5kprA-5e26A:
82.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 401
TYR A 400
TYR A 383
 None
 0.69A 5lakA-5e26A:
undetectable
5lakI-5e26A:
undetectable		 5lakA-5e26A:
22.02
5lakI-5e26A:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 401
TYR A 400
TYR A 383
 None
 0.75A 5lakC-5e26A:
undetectable
5lakJ-5e26A:
undetectable		 5lakC-5e26A:
22.02
5lakJ-5e26A:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 311
LEU A 331
PRO A 212
LEU A 252
LEU A 225
 None
None
UNX  A 605 ( 4.3A)
None
None
 1.03A 5ljeA-5e26A:
undetectable		 5ljeA-5e26A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 388
PHE A 519
ILE A 390
ILE A 504
VAL A 517
 None
 0.94A 5uvmB-5e26A:
undetectable		 5uvmB-5e26A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 387
VAL A 518
VAL A 520
ASP A 350
 None
 0.69A 5y9mX-5e26A:
undetectable		 5y9mX-5e26A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 556
GLY A 345
ILE A 346
ASP A 217
 None
None
None
UNX  A 604 ( 3.5A)
 0.97A 6ag0C-5e26A:
undetectable		 6ag0C-5e26A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 517
PHE A 550
GLY A 502
GLY A 544
 None
 0.76A 6eu9D-5e26A:
undetectable		 6eu9D-5e26A:
14.29