SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 THR A 242
GLY A 216
THR A  77
GLN A 175
ILE A  51
 None
EDO  A 303 (-3.5A)
None
None
None
 1.31A 2akeA-5e2fA:
undetectable		 2akeA-5e2fA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		4 / 4 THR A 215
THR A 217
ASP A 246
ASP A  45
 EDO  A 303 (-3.7A)
EDO  A 303 (-3.8A)
None
None
 1.50A 2f8lA-5e2fA:
undetectable		 2f8lA-5e2fA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 LEU A  84
LEU A 179
ILE A 170
GLY A 151
LEU A 145
 None
 1.24A 2j7xA-5e2fA:
undetectable		 2j7xA-5e2fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		4 / 4 VAL A 241
THR A 242
VAL A 244
GLY A  48
 None
 1.17A 2p2fB-5e2fA:
undetectable		 2p2fB-5e2fA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		4 / 8 ILE A 196
TYR A 128
ASP A  94
ARG A  93
 None
 0.87A 2v57A-5e2fA:
undetectable		 2v57A-5e2fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		4 / 8 ILE A 196
TYR A 128
ASP A  94
ARG A  93
 None
 0.86A 2v57C-5e2fA:
undetectable		 2v57C-5e2fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
 None
 1.35A 2vdyA-5e2fA:
undetectable		 2vdyA-5e2fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
 None
 1.35A 2vdyB-5e2fA:
undetectable		 2vdyB-5e2fA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 9 PHE A  43
LEU A 264
ILE A  51
LEU A 179
VAL A  34
 None
 1.35A 3m7rA-5e2fA:
undetectable		 3m7rA-5e2fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
 None
 1.38A 4c49C-5e2fA:
undetectable		 4c49C-5e2fA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
 None
 1.34A 4c49D-5e2fA:
undetectable		 4c49D-5e2fA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 LEU A  84
LEU A 179
ILE A 170
GLY A 151
LEU A 145
 None
 1.26A 4j26A-5e2fA:
undetectable		 4j26A-5e2fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		4 / 4 LEU A  87
ARG A 140
ILE A  85
ILE A 136
 None
 1.25A 5dzk2-5e2fA:
undetectable
5dzkM-5e2fA:
undetectable
5dzkN-5e2fA:
undetectable		 5dzk2-5e2fA:
14.29
5dzkM-5e2fA:
20.15
5dzkN-5e2fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		4 / 4 GLN A 175
VAL A 241
GLU A 176
ILE A  51
 None
 1.23A 5jncA-5e2fA:
undetectable		 5jncA-5e2fA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		6 / 12 SER A  76
SER A 124
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 (-3.0A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.81A 6b5yB-5e2fA:
17.6		 6b5yB-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		6 / 12 SER A  76
SER A 124
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 (-3.0A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.80A 6b5yD-5e2fA:
17.3		 6b5yD-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A  76
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.19A 6b68B-5e2fA:
17.7		 6b68B-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		6 / 12 SER A  76
SER A 124
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 (-3.0A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.71A 6b69A-5e2fA:
17.6
6b69B-5e2fA:
17.5		 6b69A-5e2fA:
14.07
6b69B-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		6 / 12 SER A  76
SER A 124
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 (-3.0A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.72A 6b69D-5e2fA:
17.4		 6b69D-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A  76
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.19A 6b6aD-5e2fA:
17.6		 6b6aD-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A  76
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.31A 6b6cA-5e2fA:
17.6		 6b6cA-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		6 / 12 SER A  76
SER A 124
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 (-3.0A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.74A 6b6eA-5e2fA:
17.7		 6b6eA-5e2fA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 5e2f BETA-LACTAMASE YBXI
(Bacillus
subtilis) 		5 / 12 SER A  76
LYS A 214
THR A 215
GLY A 216
THR A 217
 ALY  A  79 ( 2.4A)
EDO  A 303 ( 4.4A)
EDO  A 303 (-3.7A)
EDO  A 303 (-3.5A)
EDO  A 303 (-3.8A)
 0.32A 6b6fA-5e2fA:
17.3		 6b6fA-5e2fA:
14.07