SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		4 / 7 TYR A 145
ILE A  57
HIS A 107
GLU A 267
 None
 1.02A 1j96B-5e2gA:
undetectable		 1j96B-5e2gA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A  58
ASN A 147
TYR A 217
THR A 311
GLY A 312
 None
 1.25A 1kvlA-5e2gA:
52.0		 1kvlA-5e2gA:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		6 / 10 TYR A 145
ASN A 147
TYR A 217
LYS A 310
THR A 311
GLY A 312
 None
 0.36A 1kvlA-5e2gA:
52.0		 1kvlA-5e2gA:
43.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_A_CHCA202_1
(BILE ACID RECEPTOR)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 MET A 191
MET A 207
ARG A 206
ILE A  57
TRP A 213
 None
 1.35A 1osvA-5e2gA:
0.0		 1osvA-5e2gA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 156
GLY A  97
GLY A  85
ILE A 127
TYR A 129
 None
 1.18A 1p91A-5e2gA:
undetectable		 1p91A-5e2gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		4 / 5 PHE A 165
LEU A 101
MET A 161
LEU A 243
 None
None
None
SCN  A 402 ( 4.0A)
 1.42A 1skxA-5e2gA:
undetectable		 1skxA-5e2gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  57
GLY A  58
GLY A 315
ALA A 216
LEU A  64
 None
 1.00A 1vptA-5e2gA:
undetectable		 1vptA-5e2gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		4 / 5 ASP A  71
LEU A  68
MET A 169
ARG A 172
 SCN  A 402 ( 3.7A)
None
None
SCN  A 402 ( 4.7A)
 1.25A 2gj5A-5e2gA:
undetectable		 2gj5A-5e2gA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A  91
ILE A 127
PRO A 109
VAL A 148
GLY A 151
 None
 1.37A 2qd4B-5e2gA:
undetectable		 2qd4B-5e2gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		3 / 3 PRO A 259
GLY A 281
TYR A 269
 None
 0.60A 2vouA-5e2gA:
undetectable		 2vouA-5e2gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		3 / 3 PRO A 259
GLY A 281
TYR A 269
 None
 0.62A 2vouB-5e2gA:
undetectable		 2vouB-5e2gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		3 / 3 PRO A 259
GLY A 281
TYR A 269
 None
 0.61A 2vouC-5e2gA:
undetectable		 2vouC-5e2gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 130
TRP A 133
GLY A 111
 None
 0.63A 3l35A-5e2gA:
undetectable
3l35H-5e2gA:
undetectable		 3l35A-5e2gA:
7.87
3l35H-5e2gA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 130
TRP A 133
GLY A 111
 None
 0.64A 3l35B-5e2gA:
undetectable
3l35K-5e2gA:
undetectable		 3l35B-5e2gA:
7.87
3l35K-5e2gA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 126
LEU A  91
VAL A 148
GLY A 151
LEU A 156
 None
 0.90A 3nt1A-5e2gA:
undetectable		 3nt1A-5e2gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 126
LEU A  91
VAL A 148
GLY A 151
LEU A 156
 None
 0.92A 3nt1B-5e2gA:
undetectable		 3nt1B-5e2gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 126
LEU A  91
VAL A 148
GLY A 151
LEU A 156
 None
 1.08A 3pghD-5e2gA:
undetectable		 3pghD-5e2gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 342
LYS A 346
ASN A 282
 None
 0.95A 4y1dA-5e2gA:
undetectable
4y1dD-5e2gA:
undetectable		 4y1dA-5e2gA:
19.71
4y1dD-5e2gA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 9 LEU A 104
ASP A  82
LEU A 153
LEU A 264
ALA A  69
 None
 0.95A 5dqfA-5e2gA:
undetectable		 5dqfA-5e2gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 PHE A  55
LEU A 352
ILE A  27
GLY A  26
ILE A  25
 None
 0.88A 5ifuA-5e2gA:
undetectable		 5ifuA-5e2gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5e2g BETA-LACTAMASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 126
LEU A  91
VAL A 148
GLY A 151
LEU A 156
 None
 0.96A 5jvzA-5e2gA:
undetectable		 5jvzA-5e2gA:
19.61