SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 308
ARG A 341
TYR A  17
LEU A  13
 None
 1.07A 1ibgL-5e2hA:
undetectable		 1ibgL-5e2hA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A  57
ASN A 146
TYR A 216
THR A 308
GLY A 309
 None
CL  A 402 ( 4.8A)
None
None
None
 1.35A 1kvlA-5e2hA:
54.7		 1kvlA-5e2hA:
41.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 10 LEU A 113
GLN A 114
TYR A 144
LYS A 307
THR A 308
GLY A 309
 None
 0.71A 1kvlA-5e2hA:
54.7		 1kvlA-5e2hA:
41.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		7 / 10 LEU A 113
TYR A 144
ASN A 146
TYR A 216
LYS A 307
THR A 308
GLY A 309
 None
None
CL  A 402 ( 4.8A)
None
None
None
None
 0.25A 1kvlA-5e2hA:
54.7		 1kvlA-5e2hA:
41.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 11 THR A 311
GLY A 313
GLY A 196
ILE A  56
LEU A 331
ALA A 316
 None
 1.44A 1x7pA-5e2hA:
undetectable
1x7pB-5e2hA:
undetectable		 1x7pA-5e2hA:
24.66
1x7pB-5e2hA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
LYS A  61
ASN A 146
LYS A 307
GLY A 309
ASP A 312
 None
None
CL  A 402 ( 4.8A)
None
None
None
 0.59A 1ymxA-5e2hA:
15.9		 1ymxA-5e2hA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
LYS A  61
ASN A 146
LYS A 307
GLY A 309
ASP A 312
 None
None
CL  A 402 ( 4.8A)
None
None
None
 0.58A 1ymxB-5e2hA:
15.9		 1ymxB-5e2hA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
LYS A  61
LYS A 307
GLY A 309
SER A 310
ASP A 312
 None
 0.90A 1ymxB-5e2hA:
15.9		 1ymxB-5e2hA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 215
GLY A 217
MET A 168
LEU A 173
LEU A 176
 None
 0.90A 2hw2A-5e2hA:
undetectable		 2hw2A-5e2hA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 167
THR A 165
ILE A 155
HIS A 154
 None
 1.14A 2jfaB-5e2hA:
undetectable		 2jfaB-5e2hA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PRO A 258
GLY A 280
TYR A 268
 None
 0.69A 2vouA-5e2hA:
undetectable		 2vouA-5e2hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PRO A 258
GLY A 280
TYR A 268
 None
 0.72A 2vouB-5e2hA:
undetectable		 2vouB-5e2hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PRO A 258
GLY A 280
TYR A 268
 None
 0.72A 2vouC-5e2hA:
undetectable		 2vouC-5e2hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 LYS A  61
ASN A 146
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
CL  A 402 ( 4.8A)
None
None
None
None
 0.58A 3huoA-5e2hA:
15.8		 3huoA-5e2hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LYS A  61
ASN A 146
LYS A 307
GLY A 309
ASP A 312
 None
CL  A 402 ( 4.8A)
None
None
None
 0.59A 3huoB-5e2hA:
15.8		 3huoB-5e2hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  50
ASP A 224
ASP A  51
 None
 0.91A 3jb2A-5e2hA:
undetectable		 3jb2A-5e2hA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
ARG A 341
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.78A 3ny4A-5e2hA:
15.2		 3ny4A-5e2hA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 LYS A  61
ASN A 146
LYS A 307
GLY A 309
SER A 310
ASP A 312
 None
CL  A 402 ( 4.8A)
None
None
None
None
 0.94A 3q07A-5e2hA:
15.9		 3q07A-5e2hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LYS A  61
ASN A 146
LYS A 307
GLY A 309
ASP A 312
 None
CL  A 402 ( 4.8A)
None
None
None
 0.59A 3q07B-5e2hA:
15.7		 3q07B-5e2hA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 102
GLY A 110
PRO A 147
ALA A 215
GLY A 150
 None
None
CL  A 402 ( 4.8A)
None
None
 1.32A 3v3oB-5e2hA:
undetectable		 3v3oB-5e2hA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 217
ILE A  56
VAL A 185
GLN A 169
PHE A 164
 None
None
CL  A 401 (-4.1A)
None
None
 1.06A 4fglA-5e2hA:
undetectable
4fglB-5e2hA:
undetectable		 4fglA-5e2hA:
22.07
4fglB-5e2hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A  90
PRO A  83
LEU A  87
ILE A 126
 None
 1.07A 4klrA-5e2hA:
undetectable		 4klrA-5e2hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A  34
ILE A 226
GLY A  30
ILE A 233
 None
 0.96A 4qogA-5e2hA:
undetectable
4qogB-5e2hA:
undetectable		 4qogA-5e2hA:
21.61
4qogB-5e2hA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A 145
ILE A 126
ALA A 127
MET A 125
PHE A 115
 None
 1.09A 4r29D-5e2hA:
undetectable		 4r29D-5e2hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 153
GLY A 150
SER A 156
ALA A  72
THR A  73
 None
 1.07A 4uckB-5e2hA:
undetectable		 4uckB-5e2hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A 103
ASP A  81
LEU A 152
LEU A 263
ALA A  68
 None
 0.80A 5dqfA-5e2hA:
undetectable		 5dqfA-5e2hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 THR A 311
GLY A 313
GLY A 196
ILE A  56
LEU A 331
ALA A 316
 None
 1.43A 5l0zA-5e2hA:
undetectable		 5l0zA-5e2hA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
ARG A 341
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.72A 6b5yB-5e2hA:
15.2		 6b5yB-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A  58
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.47A 6b5yD-5e2hA:
15.2		 6b5yD-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A  58
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.27A 6b68B-5e2hA:
15.2		 6b68B-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A  58
ARG A 341
LYS A 307
GLY A 309
ASP A 312
 None
 0.66A 6b68D-5e2hA:
15.2		 6b68D-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
ARG A 341
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.70A 6b6aB-5e2hA:
15.2		 6b6aB-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 SER A  58
ARG A 341
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.72A 6b6aD-5e2hA:
15.1		 6b6aD-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 SER A  58
LYS A 307
THR A 308
GLY A 309
ASP A 312
 None
 0.41A 6b6fA-5e2hA:
15.3		 6b6fA-5e2hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PHE A  63
VAL A 185
MET A 225
VAL A  59
 None
CL  A 401 (-4.1A)
None
None
 1.40A 6ekzA-5e2hA:
undetectable		 6ekzA-5e2hA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5e2h BETA-LACTAMASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 281
GLY A 315
PHE A 336
ASN A 335
ALA A 318
 None
 1.12A 6r2eE-5e2hA:
undetectable		 6r2eE-5e2hA:
22.36