SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
3 / 3 ASP A 467
ARG A 464
ILE A 483
None
0.81A 1a4gB-5e31A:
undetectable
1a4gB-5e31A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 ILE A 548
ALA A 551
THR A 346
ILE A 347
LEU A 274
None
1.21A 1dhfB-5e31A:
undetectable
1dhfB-5e31A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 8 SER A 522
ASN A 523
GLY A 541
THR A 536
None
0.88A 1jr1B-5e31A:
undetectable
1jr1B-5e31A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 ALA A 223
LEU A 241
SER A 229
ILE A 228
LEU A 200
None
1.01A 1rg7A-5e31A:
undetectable
1rg7A-5e31A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 11 PHE A 155
TYR A 134
ALA A 120
TYR A  91
VAL A  96
None
1.49A 2cojA-5e31A:
undetectable
2cojB-5e31A:
undetectable
2cojA-5e31A:
20.43
2cojB-5e31A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 LEU A 184
GLY A 276
ILE A 343
ILE A 514
ILE A 176
None
0.87A 2rkfA-5e31A:
undetectable
2rkfA-5e31A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 LEU A 184
GLY A 276
ILE A 343
ILE A 514
ILE A 176
None
0.91A 2rkgB-5e31A:
undetectable
2rkgB-5e31A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 LEU A 568
ILE A 505
ILE A 427
VAL A 650
VAL A 367
None
1.03A 2ygnA-5e31A:
undetectable
2ygnA-5e31A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 5 ALA A 208
LEU A 200
GLY A 254
THR A 248
None
0.87A 3dl9A-5e31A:
undetectable
3dl9A-5e31A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 6 ILE A 545
TYR A 418
MET A 516
ILE A 548
None
1.04A 3eteA-5e31A:
undetectable
3eteE-5e31A:
undetectable
3eteA-5e31A:
21.95
3eteE-5e31A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 5 ILE A 545
TYR A 418
MET A 516
ILE A 548
None
1.07A 3eteB-5e31A:
undetectable
3eteC-5e31A:
undetectable
3eteB-5e31A:
21.95
3eteC-5e31A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 7 MET A 516
ILE A 548
ILE A 545
TYR A 418
None
1.05A 3eteD-5e31A:
undetectable
3eteF-5e31A:
undetectable
3eteD-5e31A:
21.95
3eteF-5e31A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
ASN A 482
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.60A 3hlwB-5e31A:
16.7
3hlwB-5e31A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 5 THR A 416
SER A 412
SER A 381
ARG A 413
None
1.27A 3hlwB-5e31A:
16.8
3hlwB-5e31A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 10 ALA A 552
LEU A 376
VAL A 367
ILE A 514
LEU A 274
None
1.18A 3jw3A-5e31A:
undetectable
3jw3A-5e31A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
3 / 3 GLU A 625
GLU A 657
ASN A 655
None
0.83A 3lp9B-5e31A:
2.2
3lp9D-5e31A:
2.3
3lp9B-5e31A:
18.73
3lp9D-5e31A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 ALA A 270
GLY A 361
GLY A 360
ASP A 386
ASP A 357
None
1.07A 3m6vA-5e31A:
undetectable
3m6vA-5e31A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 ALA A 270
GLY A 361
GLY A 360
ASP A 386
ASP A 357
None
1.09A 3m6vB-5e31A:
2.6
3m6vB-5e31A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.79A 3ny4A-5e31A:
15.9
3ny4A-5e31A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 422
SER A 480
ASN A 482
LYS A 617
THR A 618
GLY A 619
None
0.79A 3sh8A-5e31A:
16.4
3sh8A-5e31A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 9 ALA A 570
LEU A 345
ASP A 178
ASN A 180
ILE A 176
None
1.19A 3wdmA-5e31A:
undetectable
3wdmA-5e31A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 10 SER A 480
ASN A 482
LYS A 617
THR A 618
GLY A 619
None
0.72A 4fh2A-5e31A:
18.2
4fh2A-5e31A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 7 VAL A  96
TYR A  91
MET A 122
LEU A 129
None
1.15A 4hxyB-5e31A:
undetectable
4hxyB-5e31A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 ILE A 548
ALA A 551
THR A 346
ILE A 347
LEU A 274
None
1.08A 4kjkA-5e31A:
undetectable
4kjkA-5e31A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
ASN A 482
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.67A 4pm5A-5e31A:
17.0
4pm5A-5e31A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 SER A 480
ASN A 482
THR A 603
LYS A 617
GLY A 619
None
0.74A 4pm7A-5e31A:
16.9
4pm7A-5e31A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
ASN A 482
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.67A 4pm9A-5e31A:
17.0
4pm9A-5e31A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 6 ALA A 534
LEU A 532
SER A 529
VAL A 462
None
1.22A 5a6iA-5e31A:
undetectable
5a6iA-5e31A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 10 SER A 422
SER A 480
ASN A 482
LYS A 617
THR A 618
GLY A 619
None
0.77A 5ghzB-5e31A:
16.2
5ghzB-5e31A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 GLY A 317
THR A 168
LEU A 332
GLU A 328
VAL A 164
None
1.22A 5hw4C-5e31A:
undetectable
5hw4C-5e31A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
4 / 6 SER A 365
GLY A 417
ASN A 546
ILE A 411
None
1.05A 5j4nA-5e31A:
undetectable
5j4nA-5e31A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.92A 6b5yB-5e31A:
16.0
6b5yB-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.97A 6b5yD-5e31A:
15.7
6b5yD-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.87A 6b68B-5e31A:
15.8
6b68B-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 422
SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.66A 6b69A-5e31A:
16.2
6b69B-5e31A:
15.9
6b69A-5e31A:
10.02
6b69B-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.85A 6b69A-5e31A:
16.2
6b69B-5e31A:
15.9
6b69A-5e31A:
10.02
6b69B-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 422
SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.68A 6b69D-5e31A:
15.8
6b69D-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 422
SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.66A 6b6aB-5e31A:
15.9
6b6aB-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.84A 6b6aB-5e31A:
15.9
6b6aB-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 422
SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.81A 6b6dA-5e31A:
15.7
6b6dA-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 422
SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
None
0.65A 6b6eA-5e31A:
15.9
6b6eA-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
6 / 12 SER A 480
THR A 603
LYS A 617
THR A 618
GLY A 619
THR A 620
None
0.84A 6b6eA-5e31A:
15.9
6b6eA-5e31A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
5 / 12 SER A 480
ASN A 482
THR A 603
LYS A 617
GLY A 619
None
0.70A 6c79A-5e31A:
16.7
6c79A-5e31A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium)
3 / 3 LYS A 297
VAL A 278
ASP A 280
None
0.29A 6fgdA-5e31A:
undetectable
6fgdA-5e31A:
21.49