SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		5 / 12 ALA A 130
THR A 272
ILE A 275
ARG A 279
THR A 131
 ALA  A 130 ( 0.0A)
THR  A 272 ( 0.8A)
ILE  A 275 ( 0.6A)
ARG  A 279 ( 0.6A)
THR  A 131 ( 0.8A)
 1.10A 1ddsA-5e37A:
undetectable		 1ddsA-5e37A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		5 / 11 PHE A 261
ALA A 203
LEU A 220
ALA A 223
VAL A 229
 PHE  A 261 ( 1.3A)
ALA  A 203 ( 0.0A)
LEU  A 220 ( 0.6A)
ALA  A 223 ( 0.0A)
VAL  A 229 ( 0.6A)
 1.02A 2bxeB-5e37A:
undetectable		 2bxeB-5e37A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		5 / 12 GLU A 216
ALA A 116
LEU A 178
ILE A 164
MET A 153
 GLU  A 216 ( 0.5A)
ALA  A 116 ( 0.0A)
LEU  A 178 ( 0.6A)
ILE  A 164 ( 0.7A)
MET  A 153 ( 0.0A)
 1.31A 2xkwB-5e37A:
undetectable		 2xkwB-5e37A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 264
GLN A 271
THR A 272
LEU A 220
 LEU  A 264 ( 0.5A)
GLN  A 271 ( 0.6A)
THR  A 272 ( 0.8A)
LEU  A 220 ( 0.6A)
 1.21A 3ce6D-5e37A:
undetectable		 3ce6D-5e37A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		4 / 8 ASP A 102
LEU A 104
SER A 176
ASN A 175
 ASP  A 102 ( 0.5A)
LEU  A 104 ( 0.6A)
SER  A 176 ( 0.0A)
ASN  A 175 ( 0.6A)
 0.98A 3lm8A-5e37A:
undetectable
3lm8C-5e37A:
undetectable		 3lm8A-5e37A:
21.21
3lm8C-5e37A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5e37 EF-HAND
DOMAIN-CONTAINING
THIOREDOXIN
(Chlamydomonas
reinhardtii) 		4 / 6 ASN A 224
VAL A 260
VAL A 262
THR A 209
 ASN  A 224 ( 0.6A)
VAL  A 260 ( 0.6A)
VAL  A 262 ( 0.5A)
THR  A 209 ( 0.9A)
 1.26A 6f32B-5e37A:
undetectable		 6f32B-5e37A:
22.68