SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
VAL A  75
ALA A 199
LEU A 196
PHE A  28
 None
 0.96A 1gs4A-5e38A:
undetectable		 1gs4A-5e38A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  32
ALA A 190
ALA A 133
VAL A 158
LEU A 196
 None
 1.36A 1hbpA-5e38A:
undetectable		 1hbpA-5e38A:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 5 MET A 131
ALA A 133
TYR A 191
ILE A 192
ASP A 198
 None
 0.59A 1upfA-5e38A:
25.0		 1upfA-5e38A:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 5 MET A 131
ALA A 133
TYR A 191
ILE A 192
ASP A 198
 None
 0.61A 1upfC-5e38A:
25.0		 1upfC-5e38A:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 4 MET A 131
ALA A 133
TYR A 191
ILE A 192
 None
 0.50A 1upfD-5e38A:
25.4		 1upfD-5e38A:
33.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  39
LEU A  35
ARG A  19
LEU A  18
ALA A 181
 None
 1.27A 2bxeA-5e38A:
undetectable		 2bxeA-5e38A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 133
GLY A 164
GLY A 143
LEU A 142
LEU A 145
 None
 1.00A 2hw2A-5e38A:
undetectable		 2hw2A-5e38A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
VAL A  75
ALA A 199
LEU A 196
PHE A  28
 None
 1.05A 2oz7A-5e38A:
undetectable		 2oz7A-5e38A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 177
MET A  82
VAL A 155
THR A 139
GLY A 136
 None
 1.39A 6brdA-5e38A:
undetectable		 6brdA-5e38A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  25
PHE A  28
GLY A 200
ALA A  78
LEU A  32
 None
 1.04A 6dwnD-5e38A:
undetectable		 6dwnD-5e38A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  -4
ASP A 183
ILE A 182
ILE A 165
 None
 0.96A 6fbnA-5e38A:
undetectable		 6fbnA-5e38A:
21.17