SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		5 / 12 ILE A   4
VAL A 152
LEU A 122
VAL A 120
LEU A 106
 None
 0.90A 2aw1A-5e3bA:
undetectable		 2aw1A-5e3bA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		5 / 12 LEU A 145
ALA A 114
VAL A  19
VAL A 152
ILE A 150
 None
 1.16A 2o4lA-5e3bA:
undetectable		 2o4lA-5e3bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		4 / 6 ARG A  43
GLU A  74
GLN A  46
PRO A  47
 None
 1.38A 3gclA-5e3bA:
undetectable		 3gclA-5e3bA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		5 / 9 ALA A 114
ILE A 150
ARG A 148
GLY A 107
VAL A 109
 None
 1.22A 4a3uA-5e3bA:
undetectable		 4a3uA-5e3bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		5 / 11 ALA A  50
GLU A  48
ASN A  27
ASN A  81
TRP A  54
 None
None
EDO  A1002 ( 4.6A)
None
None
 1.24A 4jdsD-5e3bA:
undetectable		 4jdsD-5e3bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		5 / 12 ALA A  50
GLU A  48
ASN A  27
ASN A  81
TRP A  54
 None
None
EDO  A1002 ( 4.6A)
None
None
 1.23A 4jlgA-5e3bA:
undetectable		 4jlgA-5e3bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		3 / 3 PRO A  96
VAL A  25
HIS A  24
 None
 0.84A 4pevC-5e3bA:
3.7		 4pevC-5e3bA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		5 / 11 ALA A  50
GLU A  48
ASN A  27
ASN A  81
TRP A  54
 None
None
EDO  A1002 ( 4.6A)
None
None
 1.12A 5ayfA-5e3bA:
undetectable		 5ayfA-5e3bA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5e3b MACRODOMAIN PROTEIN
(Streptomyces
coelicolor) 		3 / 3 TRP A 134
ILE A   4
SER A 142
 None
 1.01A 5gqbA-5e3bA:
undetectable		 5gqbA-5e3bA:
15.16