SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 7 LEU A  46
LEU A  49
SER A  53
THR A 716
 None
 0.91A 1dvxA-5e3cA:
undetectable		 1dvxA-5e3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 VAL A  99
GLY A 104
LEU A  49
GLU A 712
 None
 0.90A 1fduD-5e3cA:
undetectable		 1fduD-5e3cA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 5 PHE A 499
GLY A 636
SER A 487
THR A 631
 None
 1.36A 1icvA-5e3cA:
undetectable
1icvB-5e3cA:
undetectable		 1icvA-5e3cA:
15.47
1icvB-5e3cA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 SER A  38
GLY A 330
ALA A 333
VAL A 378
LEU A 376
 None
 1.05A 1jg4A-5e3cA:
undetectable		 1jg4A-5e3cA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 8 SER A 190
PHE A 244
VAL A 214
SER A 173
 None
 1.02A 1kb9A-5e3cA:
undetectable
1kb9C-5e3cA:
undetectable
1kb9D-5e3cA:
undetectable
1kb9E-5e3cA:
undetectable		 1kb9A-5e3cA:
20.73
1kb9C-5e3cA:
19.07
1kb9D-5e3cA:
16.09
1kb9E-5e3cA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 ILE A 392
GLU A 507
ASN A 394
TYR A 196
GLU A 329
 None
 1.33A 1n6cA-5e3cA:
undetectable		 1n6cA-5e3cA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 VAL A 259
ILE A 312
MET A 103
ARG A 248
 None
 0.91A 1opjB-5e3cA:
undetectable		 1opjB-5e3cA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 4 VAL A 334
ALA A  22
LEU A 686
PHE A  23
 None
 1.26A 1q97B-5e3cA:
undetectable		 1q97B-5e3cA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 8 MET A 151
ALA A  56
LEU A  50
VAL A  99
 None
 0.96A 1sn5C-5e3cA:
undetectable		 1sn5C-5e3cA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		3 / 3 ARG A 548
TYR A 435
LYS A 439
 None
 1.08A 1uujB-5e3cA:
1.6		 1uujB-5e3cA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 4 LEU A 516
SER A 519
TYR A 517
LEU A 618
 None
 1.23A 1xz1A-5e3cA:
undetectable		 1xz1A-5e3cA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 4 LEU A 516
SER A 519
TYR A 517
LEU A 618
 None
 1.25A 1xz3A-5e3cA:
undetectable		 1xz3A-5e3cA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 10 LEU A  63
ALA A  96
LEU A  93
PRO A 116
LEU A 123
 None
 1.11A 1yi4A-5e3cA:
undetectable		 1yi4A-5e3cA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 GLY A 515
TRP A 543
LEU A 622
ILE A 539
HIS A 521
 None
 1.45A 2a58A-5e3cA:
undetectable
2a58E-5e3cA:
undetectable		 2a58A-5e3cA:
12.31
2a58E-5e3cA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 ILE A 539
HIS A 521
GLY A 515
TRP A 543
LEU A 622
 None
 1.45A 2a58C-5e3cA:
undetectable
2a58D-5e3cA:
undetectable		 2a58C-5e3cA:
12.31
2a58D-5e3cA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 5 LEU A 354
LEU A 353
LEU A 449
LEU A 452
 None
 1.03A 2ab2B-5e3cA:
undetectable		 2ab2B-5e3cA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 5 LEU A 449
LEU A 452
LEU A 354
LEU A 353
 None
 1.04A 2ab2B-5e3cA:
undetectable		 2ab2B-5e3cA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 10 ALA A 265
ALA A  34
LEU A 379
LEU A  26
LEU A 278
 None
 1.03A 2bxqA-5e3cA:
3.6		 2bxqA-5e3cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 7 ALA A  47
GLY A  45
GLY A  44
PHE A 314
 None
 0.71A 2c49B-5e3cA:
undetectable		 2c49B-5e3cA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 4 GLN A 717
GLU A 713
ILE A 714
PRO A 253
 None
 1.42A 2fcnA-5e3cA:
undetectable		 2fcnA-5e3cA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 4 ASP A 633
LEU A 640
GLY A 637
ARG A 624
 None
 1.26A 2j2pD-5e3cA:
undetectable
2j2pE-5e3cA:
undetectable		 2j2pD-5e3cA:
13.20
2j2pE-5e3cA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 10 SER A 108
ILE A 386
ASN A 102
VAL A 415
ILE A  12
 MG  A 804 (-2.8A)
None
MG  A 804 (-3.3A)
None
None
 1.08A 2nnhB-5e3cA:
undetectable		 2nnhB-5e3cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 ALA A 533
ASP A 534
GLU A 536
ARG A 611
 None
 1.38A 2ouzA-5e3cA:
undetectable		 2ouzA-5e3cA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 5 ILE A 168
SER A  53
PRO A  54
PRO A  57
 None
 1.37A 3bjwC-5e3cA:
undetectable		 3bjwC-5e3cA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.42A 3mbhA-5e3cA:
undetectable		 3mbhA-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.41A 3mbhB-5e3cA:
undetectable		 3mbhB-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.43A 3mbhC-5e3cA:
undetectable		 3mbhC-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.45A 3mbhD-5e3cA:
undetectable		 3mbhD-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.41A 3mbhE-5e3cA:
undetectable		 3mbhE-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 VAL A 126
LEU A  80
HIS A  78
GLN A  70
TYR A  89
 None
 1.44A 3mbhF-5e3cA:
undetectable		 3mbhF-5e3cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 LEU A 150
SER A  53
THR A 170
THR A 169
GLY A 162
 None
 1.23A 3sfuC-5e3cA:
undetectable		 3sfuC-5e3cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 9 GLY A 515
LEU A 520
LEU A 516
ASN A 542
ILE A 539
 None
 1.22A 3wdmA-5e3cA:
undetectable		 3wdmA-5e3cA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 10 GLY A 515
LEU A 520
LEU A 516
ASN A 542
ILE A 539
 None
 1.18A 3wdmB-5e3cA:
undetectable		 3wdmB-5e3cA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 7 ALA A 217
PHE A 314
ALA A  47
LEU A 255
 None
 0.93A 4du2B-5e3cA:
undetectable		 4du2B-5e3cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 PHE A 314
GLY A  44
LEU A 255
VAL A 258
 None
 0.94A 4dubA-5e3cA:
undetectable		 4dubA-5e3cA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 GLU A 507
GLY A 323
ASN A 394
TYR A 196
GLU A 329
 None
K  A 803 (-3.8A)
None
None
None
 1.26A 4jlgA-5e3cA:
undetectable		 4jlgA-5e3cA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 11 GLU A 507
GLY A 323
ASN A 394
TYR A 196
GLU A 329
 None
K  A 803 (-3.8A)
None
None
None
 1.34A 4jlgB-5e3cA:
undetectable		 4jlgB-5e3cA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 LEU A 625
HIS A 455
HIS A 450
GLU A 508
 None
ZN  A 801 (-3.3A)
ZN  A 801 (-3.2A)
ZN  A 801 (-2.2A)
 0.85A 4pahA-5e3cA:
undetectable		 4pahA-5e3cA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 GLY A  44
ALA A  41
GLN A 261
ILE A 254
ILE A 714
 None
 1.11A 4uw0A-5e3cA:
undetectable		 4uw0A-5e3cA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 LEU A  93
PRO A  72
GLU A  86
TYR A  89
 None
 1.23A 4z4gA-5e3cA:
undetectable		 4z4gA-5e3cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 LEU A 200
PRO A  54
TRP A 726
PHE A 201
VAL A 246
 None
 1.41A 5dlvB-5e3cA:
undetectable		 5dlvB-5e3cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 7 GLU A 508
GLY A 454
GLY A 515
ALA A 451
 ZN  A 801 (-2.2A)
None
None
None
 0.83A 5e26A-5e3cA:
undetectable
5e26B-5e3cA:
undetectable		 5e26A-5e3cA:
21.25
5e26B-5e3cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 7 ALA A 451
GLU A 508
GLY A 454
GLY A 515
 None
ZN  A 801 (-2.2A)
None
None
 0.80A 5e26A-5e3cA:
undetectable
5e26B-5e3cA:
undetectable		 5e26A-5e3cA:
21.25
5e26B-5e3cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 7 GLU A 508
GLY A 454
GLY A 515
ALA A 451
 ZN  A 801 (-2.2A)
None
None
None
 0.84A 5e26C-5e3cA:
undetectable
5e26D-5e3cA:
undetectable		 5e26C-5e3cA:
21.25
5e26D-5e3cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 8 ALA A 451
GLU A 508
GLY A 454
GLY A 515
 None
ZN  A 801 (-2.2A)
None
None
 0.82A 5e26C-5e3cA:
undetectable
5e26D-5e3cA:
undetectable		 5e26C-5e3cA:
21.25
5e26D-5e3cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 8 ASN A 545
TRP A 564
HIS A 568
THR A 425
 None
 1.40A 5hqaA-5e3cA:
undetectable		 5hqaA-5e3cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 4 GLN A 256
VAL A 259
GLU A 263
ILE A 282
 None
 1.26A 5jncA-5e3cA:
undetectable		 5jncA-5e3cA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		5 / 12 ALA A  40
VAL A 258
GLY A 330
TYR A  43
PHE A 328
 None
 1.20A 5n5dA-5e3cA:
undetectable		 5n5dA-5e3cA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		3 / 3 VAL A 214
VAL A 246
GLN A 191
 None
 0.66A 5qgmA-5e3cA:
undetectable		 5qgmA-5e3cA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		3 / 3 MET A 546
GLU A 508
ARG A 572
 None
ZN  A 801 (-2.2A)
None
 0.94A 5tjyA-5e3cA:
undetectable		 5tjyA-5e3cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		3 / 3 MET A 546
GLU A 508
ARG A 572
 None
ZN  A 801 (-2.2A)
None
 0.82A 5tjzA-5e3cA:
undetectable		 5tjzA-5e3cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 8 ILE A 485
PHE A 363
THR A 481
PRO A 479
 None
 1.06A 5x23A-5e3cA:
undetectable		 5x23A-5e3cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		3 / 3 LYS A 113
ASN A 105
SER A  53
 None
 0.91A 5yw0A-5e3cA:
undetectable		 5yw0A-5e3cA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 PHE A 285
GLY A 313
TYR A 395
TYR A 311
 None
 1.25A 6ag0C-5e3cA:
undetectable		 6ag0C-5e3cA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		3 / 3 ARG A 565
PHE A 114
PHE A 556
 None
 0.97A 6nknC-5e3cA:
1.5
6nknJ-5e3cA:
undetectable		 6nknC-5e3cA:
15.73
6nknJ-5e3cA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens) 		4 / 6 LEU A 625
HIS A 455
HIS A 450
GLU A 508
 None
ZN  A 801 (-3.3A)
ZN  A 801 (-3.2A)
ZN  A 801 (-2.2A)
 0.72A 6pahA-5e3cA:
undetectable		 6pahA-5e3cA:
17.29