SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 11 TRP A  89
ASP A  30
LEU A  10
PHE A  18
LEU A  14
 None
 1.07A 1xpqA-5e3eA:
undetectable		 1xpqA-5e3eA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 11 TRP A  89
ASP A  30
LEU A  10
PHE A  18
LEU A  14
 None
 1.08A 1xpqC-5e3eA:
undetectable		 1xpqC-5e3eA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5e3e CDII IMMUNITY
PROTEIN
LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION
(Yersinia
kristensenii) 		5 / 12 ASP A  74
PRO B 281
ASP A  21
ARG B 259
HIS B 175
 None
 1.23A 3topA-5e3eA:
undetectable		 3topA-5e3eA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 12 ALA A  35
PHE A  26
ILE A  52
MET A  97
PHE A  18
 None
 1.30A 3wemA-5e3eA:
undetectable		 3wemA-5e3eA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5e3e LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION
(Yersinia
kristensenii) 		4 / 5 THR B 199
GLY B 242
VAL B 255
PRO B 240
 None
 1.12A 4grkA-5e3eB:
undetectable		 4grkA-5e3eB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5e3e CDII IMMUNITY
PROTEIN
LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION
(Yersinia
kristensenii) 		4 / 7 GLU A  23
TYR A  78
GLU A  82
ARG B 247
 None
 1.15A 4mi4B-5e3eA:
undetectable
4mi4C-5e3eA:
undetectable		 4mi4B-5e3eA:
18.09
4mi4C-5e3eA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5e3e CDII IMMUNITY
PROTEIN
LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION
(Yersinia
kristensenii) 		4 / 8 GLU A  23
TYR A  78
GLU A  82
ARG B 247
 None
 1.15A 4mj8B-5e3eA:
undetectable
4mj8C-5e3eA:
undetectable		 4mj8B-5e3eA:
19.44
4mj8C-5e3eA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 11 LEU A  13
GLU A  31
ALA A  34
LEU A  33
TYR A  36
 None
 1.02A 4wg0B-5e3eA:
undetectable
4wg0C-5e3eA:
undetectable
4wg0D-5e3eA:
undetectable		 4wg0B-5e3eA:
14.67
4wg0C-5e3eA:
14.67
4wg0D-5e3eA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 11 LEU A  13
GLU A  31
ALA A  34
LEU A  33
TYR A  36
 None
 1.02A 4wg0D-5e3eA:
undetectable
4wg0E-5e3eA:
undetectable
4wg0F-5e3eA:
undetectable		 4wg0D-5e3eA:
14.67
4wg0E-5e3eA:
14.67
4wg0F-5e3eA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 11 LEU A  13
GLU A  31
ALA A  34
LEU A  33
TYR A  36
 None
 1.02A 4wg0F-5e3eA:
undetectable
4wg0G-5e3eA:
undetectable
4wg0H-5e3eA:
undetectable		 4wg0F-5e3eA:
14.67
4wg0G-5e3eA:
14.67
4wg0H-5e3eA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5e3e CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		5 / 11 LEU A  13
GLU A  31
ALA A  34
LEU A  33
TYR A  36
 None
 1.08A 4wg0J-5e3eA:
undetectable
4wg0K-5e3eA:
undetectable
4wg0L-5e3eA:
undetectable		 4wg0J-5e3eA:
14.67
4wg0K-5e3eA:
14.67
4wg0L-5e3eA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5e3e LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION
(Yersinia
kristensenii) 		5 / 12 ILE B 275
LEU B 231
THR B 208
ILE B 212
ILE B 274
 None
 1.02A 4x5gB-5e3eB:
undetectable		 4x5gB-5e3eB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e3e LARGE EXOPROTEIN
INVOLVED IN HEME
UTILIZATION OR
ADHESION
(Yersinia
kristensenii) 		4 / 6 TYR B 272
ILE B 274
ALA B 211
ASP B 220
 None
 1.12A 6hu9m-5e3eB:
undetectable
6hu9q-5e3eB:
undetectable		 6hu9m-5e3eB:
10.89
6hu9q-5e3eB:
20.98