SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 8 VAL A 188
LEU A 216
SER A 178
VAL A 180
 None
 1.22A 1jtvA-5e3qA:
undetectable		 1jtvA-5e3qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 7 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.77A 2tsrA-5e3qA:
undetectable		 2tsrA-5e3qA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 7 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.68A 4iqqB-5e3qA:
undetectable		 4iqqB-5e3qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 7 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.56A 4iqqC-5e3qA:
undetectable		 4iqqC-5e3qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 8 PHE A 170
SER A  75
ALA A 154
LEU A 152
 None
 1.19A 5dzkd-5e3qA:
undetectable
5dzkr-5e3qA:
undetectable		 5dzkd-5e3qA:
23.26
5dzkr-5e3qA:
0.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 7 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.73A 5nooA-5e3qA:
undetectable		 5nooA-5e3qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 7 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.70A 5nooB-5e3qA:
undetectable		 5nooB-5e3qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 7 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.82A 5x5qC-5e3qA:
undetectable		 5x5qC-5e3qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 8 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.84A 5x5qD-5e3qA:
undetectable		 5x5qD-5e3qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Corynebacterium
glutamicum) 		4 / 8 ILE A  89
LEU A  74
GLY A 153
PHE A 170
 None
 0.84A 5x5qF-5e3qA:
undetectable		 5x5qF-5e3qA:
21.45