SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 8 ILE A 376
GLY A 375
LEU A 224
PHE A 203
 None
None
ANP  A 501 (-3.7A)
None
 0.90A 2vctC-5e3tA:
undetectable		 2vctC-5e3tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 6 ILE A 133
TYR A 138
LEU A 150
PHE A 160
 None
None
None
ANP  A 501 (-4.1A)
 0.67A 3adsA-5e3tA:
undetectable		 3adsA-5e3tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		3 / 3 PRO A 146
LEU A 147
GLN A  67
 None
 0.66A 3hznG-5e3tA:
undetectable
3hznH-5e3tA:
1.4		 3hznG-5e3tA:
19.35
3hznH-5e3tA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 6 PHE A 116
HIS A  72
THR A  71
VAL A  74
 None
 1.17A 3lb3A-5e3tA:
undetectable		 3lb3A-5e3tA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 6 PHE A 116
HIS A  72
THR A  71
VAL A  74
 None
 1.03A 3lb3B-5e3tA:
1.1		 3lb3B-5e3tA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 7 ILE A 379
LEU A 292
ASP A 288
THR A 284
 None
 1.01A 4mmcA-5e3tA:
undetectable		 4mmcA-5e3tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		5 / 12 PHE A 131
ILE A 379
LEU A 192
PHE A 189
LEU A 185
 None
 0.92A 4pd4C-5e3tA:
undetectable		 4pd4C-5e3tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 8 MET A 221
PHE A 203
ALA A 178
LEU A 181
 None
 0.98A 4rkuA-5e3tA:
undetectable
4rkuJ-5e3tA:
undetectable		 4rkuA-5e3tA:
18.51
4rkuJ-5e3tA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 7 MET A 221
PHE A 203
ALA A 178
LEU A 181
 None
 1.02A 4xk8A-5e3tA:
undetectable		 4xk8A-5e3tA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 5 ASP A 260
ARG A 244
LEU A 199
MET A 285
 None
 1.35A 5tuiB-5e3tA:
undetectable		 5tuiB-5e3tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 8 ILE A 169
ARG A 227
GLU A 145
SER A 141
 ANP  A 501 (-4.5A)
None
None
None
 1.08A 6c06C-5e3tA:
undetectable		 6c06C-5e3tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA
(Danio
rerio) 		4 / 8 ILE A 218
VAL A  92
GLU A  94
SER A  95
 None
 0.67A 6fbvC-5e3tA:
undetectable		 6fbvC-5e3tA:
16.62