SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.90A 1j36A-5e3xA:
22.7		 1j36A-5e3xA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.90A 1j36B-5e3xA:
22.8		 1j36B-5e3xA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 11 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.92A 1j37A-5e3xA:
22.7		 1j37A-5e3xA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 11 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.92A 1j37B-5e3xA:
22.7		 1j37B-5e3xA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.95A 1o86A-5e3xA:
23.8		 1o86A-5e3xA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 5 VAL A 293
GLY A 294
VAL A 292
TRP A 323
 None
 1.33A 1tkqB-5e3xA:
undetectable		 1tkqB-5e3xA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		6 / 12 ALA A 338
GLU A 179
LEU A 175
LEU A 379
THR A 342
GLY A 380
 None
 1.39A 1uwhA-5e3xA:
undetectable		 1uwhA-5e3xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 11 ILE A 248
ILE A 244
TYR A 304
GLY A 302
LEU A 322
 None
 1.18A 2azyA-5e3xA:
undetectable		 2azyA-5e3xA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.98A 2c6nA-5e3xA:
22.0		 2c6nA-5e3xA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 1.00A 2c6nB-5e3xA:
22.1		 2c6nB-5e3xA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 6 LEU A 208
TYR A 207
ILE A 252
GLY A 302
 None
 0.94A 2du8B-5e3xA:
undetectable		 2du8B-5e3xA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 6 LEU A 204
ASN A 327
ILE A 244
PHE A 200
 None
 1.16A 2jn3A-5e3xA:
undetectable		 2jn3A-5e3xA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 6 THR A 336
ARG A 335
THR A 225
ASP A 218
 None
 1.29A 2okcB-5e3xA:
undetectable		 2okcB-5e3xA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 11 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.96A 2x8zA-5e3xA:
22.8		 2x8zA-5e3xA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.95A 2x91A-5e3xA:
23.0		 2x91A-5e3xA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 292
TRP A 300
TRP A 323
 None
 1.17A 2xdcA-5e3xA:
undetectable
2xdcB-5e3xA:
undetectable		 2xdcA-5e3xA:
5.65
2xdcB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 293
TRP A 300
TRP A 323
 None
 1.13A 2xdcA-5e3xA:
undetectable
2xdcB-5e3xA:
undetectable		 2xdcA-5e3xA:
5.65
2xdcB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 293
TRP A 323
TRP A 300
 None
 0.94A 2xdcA-5e3xA:
undetectable
2xdcB-5e3xA:
undetectable		 2xdcA-5e3xA:
5.65
2xdcB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TRP A 300
VAL A 293
TRP A 323
 None
 0.92A 2xdcA-5e3xA:
undetectable
2xdcB-5e3xA:
undetectable		 2xdcA-5e3xA:
5.65
2xdcB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TRP A 323
VAL A 292
TRP A 300
 None
 1.16A 2xdcA-5e3xA:
undetectable
2xdcB-5e3xA:
undetectable		 2xdcA-5e3xA:
5.65
2xdcB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TRP A 323
VAL A 293
TRP A 300
 None
 1.10A 2xdcA-5e3xA:
undetectable
2xdcB-5e3xA:
undetectable		 2xdcA-5e3xA:
5.65
2xdcB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 5 ASP A  71
ILE A  70
GLU A   2
LYS A   5
 None
 1.27A 2xrzA-5e3xA:
1.9
2xrzB-5e3xA:
2.2		 2xrzA-5e3xA:
23.10
2xrzB-5e3xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 292
TRP A 300
TRP A 323
 None
 1.17A 2y5mA-5e3xA:
undetectable
2y5mB-5e3xA:
undetectable		 2y5mA-5e3xA:
5.65
2y5mB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 293
TRP A 300
TRP A 323
 None
 1.11A 2y5mA-5e3xA:
undetectable
2y5mB-5e3xA:
undetectable		 2y5mA-5e3xA:
5.65
2y5mB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 293
TRP A 323
TRP A 300
 None
 0.93A 2y5mA-5e3xA:
undetectable
2y5mB-5e3xA:
undetectable		 2y5mA-5e3xA:
5.65
2y5mB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 292
TRP A 300
TRP A 323
 None
 1.16A 2y6nA-5e3xA:
undetectable
2y6nB-5e3xA:
undetectable		 2y6nA-5e3xA:
5.65
2y6nB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 293
TRP A 300
TRP A 323
 None
 1.12A 2y6nA-5e3xA:
undetectable
2y6nB-5e3xA:
undetectable		 2y6nA-5e3xA:
5.65
2y6nB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 VAL A 293
TRP A 323
TRP A 300
 None
 0.92A 2y6nA-5e3xA:
undetectable
2y6nB-5e3xA:
undetectable		 2y6nA-5e3xA:
5.65
2y6nB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TRP A 300
VAL A 293
TRP A 323
 None
 0.92A 2y6nA-5e3xA:
undetectable
2y6nB-5e3xA:
undetectable		 2y6nA-5e3xA:
5.65
2y6nB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TRP A 323
VAL A 292
TRP A 300
 None
 1.15A 2y6nA-5e3xA:
undetectable
2y6nB-5e3xA:
undetectable		 2y6nA-5e3xA:
5.65
2y6nB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TRP A 323
VAL A 293
TRP A 300
 None
 1.11A 2y6nA-5e3xA:
undetectable
2y6nB-5e3xA:
undetectable		 2y6nA-5e3xA:
5.65
2y6nB-5e3xA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 ALA A 415
GLN A 416
ASN A 411
VAL A 174
ILE A 171
 None
 1.08A 3e00A-5e3xA:
undetectable		 3e00A-5e3xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 HIS A 253
GLU A 254
HIS A 257
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
 0.19A 3kecB-5e3xA:
2.3		 3kecB-5e3xA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 VAL A 329
ASN A 327
TYR A 485
PHE A 473
TYR A 476
 None
 1.36A 3q5pA-5e3xA:
undetectable		 3q5pA-5e3xA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 6 HIS A 257
ASP A 282
SER A 276
PRO A 227
 CO  A 501 (-3.3A)
None
None
None
 0.98A 4apjA-5e3xA:
23.7
4apjP-5e3xA:
undetectable		 4apjA-5e3xA:
24.48
4apjP-5e3xA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 11 HIS A 253
GLU A 254
HIS A 257
GLU A 283
TYR A 407
 CO  A 501 (-3.3A)
CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
 0.91A 4c2pA-5e3xA:
23.4		 4c2pA-5e3xA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 4 LEU A 409
ILE A 460
GLY A 410
PHE A 281
 None
 0.85A 4dc3A-5e3xA:
undetectable		 4dc3A-5e3xA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 TYR A 343
HIS A 253
ARG A 287
 None
CO  A 501 (-3.3A)
None
 1.16A 4htfA-5e3xA:
undetectable		 4htfA-5e3xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 5 HIS A 222
THR A 336
ARG A 335
HIS A 253
 None
None
None
CO  A 501 (-3.3A)
 1.27A 4hvcB-5e3xA:
undetectable		 4hvcB-5e3xA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 6 PHE A 401
ILE A 358
ARG A 131
VAL A 367
 None
 1.28A 4mk4B-5e3xA:
undetectable		 4mk4B-5e3xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 GLU A 254
HIS A 253
GLU A 283
TYR A 403
TYR A 407
 CO  A 501 ( 4.8A)
CO  A 501 (-3.3A)
CO  A 501 (-2.7A)
None
None
 1.38A 4r7lA-5e3xA:
6.3		 4r7lA-5e3xA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 8 ASN A 226
PRO A 227
PHE A 224
TYR A 403
 None
 1.44A 4v2zC-5e3xA:
undetectable		 4v2zC-5e3xA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 11 TYR A 207
SER A 296
LYS A 480
GLU A 428
GLY A 434
 None
 1.48A 4zjoD-5e3xA:
undetectable		 4zjoD-5e3xA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 4 GLN A 105
THR A 101
GLU A  39
LEU A  21
 None
 1.35A 5m66A-5e3xA:
undetectable		 5m66A-5e3xA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		3 / 3 GLN A 392
TRP A 371
VAL A 383
 None
 1.09A 6auuA-5e3xA:
undetectable		 6auuA-5e3xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		5 / 12 VAL A 463
PHE A 281
PHE A 164
THR A 406
GLY A 280
 None
 1.41A 6brdA-5e3xA:
undetectable		 6brdA-5e3xA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1
(Fervidobacterium
islandicum) 		4 / 4 LEU A 322
ASP A 186
PRO A 187
ARG A 245
 None
 1.23A 6fgdA-5e3xA:
undetectable		 6fgdA-5e3xA:
22.12