SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		4 / 6 GLY A 153
ILE A 151
GLN A 155
SER A 148
 MPD  A 302 (-4.0A)
None
None
None
 0.81A 1rs7B-5e44A:
undetectable		 1rs7B-5e44A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		5 / 9 LEU A 206
GLU A 168
ALA A 172
GLU A 156
LEU A 159
 None
None
MPD  A 302 ( 4.7A)
MPD  A 302 (-4.1A)
None
 1.38A 2azqA-5e44A:
undetectable		 2azqA-5e44A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		5 / 10 PHE A 218
ARG A 169
ALA A 166
LEU A 170
ALA A 171
 None
 1.50A 2wscB-5e44A:
undetectable		 2wscB-5e44A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		5 / 9 PHE A 218
ARG A 169
ALA A 166
LEU A 170
ALA A 171
 None
 1.49A 2wsfB-5e44A:
undetectable		 2wsfB-5e44A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		4 / 4 VAL A  99
TYR A  69
VAL A 121
SER A 119
 None
 1.22A 2x45B-5e44A:
undetectable		 2x45B-5e44A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		4 / 7 ILE A 200
ARG A 197
VAL A 226
MET A 223
 None
 1.08A 4f4dA-5e44A:
undetectable		 4f4dA-5e44A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		4 / 8 ILE A 200
ARG A 197
VAL A 226
MET A 223
 None
 1.07A 4f4dB-5e44A:
undetectable		 4f4dB-5e44A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		4 / 6 GLY A 153
ILE A 151
GLN A 155
SER A 148
 MPD  A 302 (-4.0A)
None
None
None
 0.91A 4kcnA-5e44A:
undetectable		 4kcnA-5e44A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		5 / 12 ILE A 143
LEU A 146
ALA A  70
LEU A  68
LEU A 129
 None
None
SF4  A 301 ( 3.8A)
None
None
 1.19A 4m11C-5e44A:
undetectable		 4m11C-5e44A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		5 / 12 LEU A 239
ILE A 231
PHE A 181
THR A 194
LEU A 214
 None
 1.19A 6djzA-5e44A:
3.8		 6djzA-5e44A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5e44 FNR REGULATOR
(Aliivibrio
fischeri) 		5 / 12 LEU A 239
ILE A 231
PHE A 181
THR A 194
LEU A 214
 None
 1.06A 6djzB-5e44A:
3.8		 6djzB-5e44A:
21.15