SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5e4e INTERLEUKIN-4
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 LYS B  91
PRO B  92
SER B  93
 None
 0.47A 4k50I-5e4eB:
undetectable		 4k50I-5e4eB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5e4e INTERLEUKIN-4
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 ALA B 135
TYR B 134
PRO B  98
 None
 0.72A 4zdyA-5e4eB:
undetectable		 4zdyA-5e4eB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5e4e INTERLEUKIN-4
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 ASP B 146
SER B 171
TYR B 172
 None
 0.92A 5glmA-5e4eB:
undetectable		 5glmA-5e4eB:
21.25