SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		4 / 5 TYR A 170
PHE A 156
ILE A 158
ARG A 136
 None
None
None
NAG  A 501 (-3.8A)
 1.28A 1qltA-5e4iA:
undetectable		 1qltA-5e4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		4 / 5 TYR A 170
PHE A 156
ILE A 158
ARG A 136
 None
None
None
NAG  A 501 (-3.8A)
 1.30A 1qltB-5e4iA:
undetectable		 1qltB-5e4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		4 / 5 TYR A 170
PHE A 156
ILE A 158
ARG A 136
 None
None
None
NAG  A 501 (-3.8A)
 1.26A 1vaoA-5e4iA:
undetectable		 1vaoA-5e4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		4 / 5 TYR A 170
PHE A 156
ILE A 158
ARG A 136
 None
None
None
NAG  A 501 (-3.8A)
 1.26A 1vaoB-5e4iA:
undetectable		 1vaoB-5e4iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		5 / 12 GLY A 211
GLY A 209
GLY A 295
GLU A 208
VAL A 206
 None
 1.00A 2oxtC-5e4iA:
undetectable		 2oxtC-5e4iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5e4i CONTACTIN-5
(Mus
musculus) 		4 / 5 TYR A  96
ALA A 174
ALA A 470
TYR A 455
 None
 1.22A 3d91A-5e4iA:
undetectable		 3d91A-5e4iA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		5 / 9 ASP A 361
ILE A 385
GLY A 364
ILE A 365
ILE A 355
 None
 1.10A 3ekyB-5e4iA:
undetectable		 3ekyB-5e4iA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5e4i CONTACTIN-5
(Mus
musculus) 		5 / 9 ASP A 361
ILE A 385
GLY A 364
ILE A 365
ILE A 355
 None
 0.97A 3ndwB-5e4iA:
undetectable		 3ndwB-5e4iA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5e4i CONTACTIN-5
(Mus
musculus) 		3 / 3 LEU A 288
ARG A 244
ASN A 326
 None
 0.74A 3qxvD-5e4iA:
8.1		 3qxvD-5e4iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5e4i CONTACTIN-5
(Mus
musculus) 		4 / 5 LEU A 286
GLY A 264
ILE A 255
LYS A 257
 None
 1.21A 4ma8C-5e4iA:
undetectable		 4ma8C-5e4iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5e4i CONTACTIN-5
(Mus
musculus) 		3 / 3 LEU A 358
TYR A 366
SER A 344
 None
 0.87A 5iktA-5e4iA:
undetectable		 5iktA-5e4iA:
20.73