SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		5 / 6 LEU A 168
TRP A  47
PHE A 136
TYR A  99
VAL A 134
 None
 1.45A 1ibgH-5e4mA:
undetectable		 1ibgH-5e4mA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		3 / 3 SER A 119
ASP A  85
CYH A  73
 HBA  A 201 ( 4.1A)
None
HBA  A 201 ( 4.4A)
 1.13A 2br4E-5e4mA:
undetectable		 2br4E-5e4mA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		4 / 7 PHE A 136
ILE A  26
ILE A 174
GLY A  39
 None
 0.79A 2v0mB-5e4mA:
undetectable		 2v0mB-5e4mA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		4 / 7 GLY A 110
THR A 109
ILE A 108
THR A 163
 None
 0.79A 4acaC-5e4mA:
undetectable		 4acaC-5e4mA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		3 / 5 GLY A 133
GLY A 131
GLU A 128
 None
HBA  A 202 ( 4.2A)
None
 0.48A 4z2eA-5e4mA:
undetectable
4z2eD-5e4mA:
undetectable		 4z2eA-5e4mA:
17.53
4z2eD-5e4mA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		7 / 9 VAL A  48
VAL A  51
TYR A 101
ILE A 108
PHE A 111
TYR A 117
TRP A 138
 None
None
HBA  A 201 (-4.6A)
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
 1.45A 5e4dA-5e4mA:
31.8		 5e4dA-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		9 / 9 VAL A  48
VAL A  52
PHE A  71
TYR A 101
ILE A 108
PHE A 111
TYR A 117
TRP A 138
LEU A 160
 None
None
HBA  A 201 ( 4.8A)
HBA  A 201 (-4.6A)
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
HBA  A 201 ( 4.5A)
 0.47A 5e4dA-5e4mA:
31.8		 5e4dA-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		5 / 9 VAL A  51
PHE A  71
PHE A 111
TYR A 117
LEU A 160
 None
HBA  A 201 ( 4.8A)
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.5A)
 1.49A 5e4dA-5e4mA:
31.8		 5e4dA-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		8 / 11 VAL A  48
VAL A  51
TYR A 101
ILE A 103
ILE A 108
PHE A 111
TYR A 117
TRP A 138
 None
None
HBA  A 201 (-4.6A)
None
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
 1.41A 5e4dB-5e4mA:
31.2		 5e4dB-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		11 / 11 VAL A  48
VAL A  51
VAL A  52
PHE A  71
TYR A 101
ILE A 103
ILE A 108
PHE A 111
TYR A 117
TRP A 138
LEU A 160
 None
None
None
HBA  A 201 ( 4.8A)
HBA  A 201 (-4.6A)
None
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
HBA  A 201 ( 4.5A)
 0.43A 5e4dB-5e4mA:
31.2		 5e4dB-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		4 / 7 LEU A  17
MET A 100
VAL A 118
THR A 141
 None
 0.23A 5e4dA-5e4mA:
31.8
5e4dB-5e4mA:
31.2		 5e4dA-5e4mA:
100.00
5e4dB-5e4mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		4 / 8 GLN A  64
ALA A  94
GLN A  98
HIS A  91
 None
None
HBA  A 203 (-4.1A)
HBA  A 203 (-3.4A)
 1.07A 5km8A-5e4mA:
undetectable
5km8B-5e4mA:
undetectable		 5km8A-5e4mA:
20.20
5km8B-5e4mA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		3 / 3 SER A  77
ALA A  76
THR A 109
 None
 0.72A 5n0xB-5e4mA:
undetectable		 5n0xB-5e4mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		3 / 3 TYR A  99
SER A 122
TRP A  35
 None
 0.77A 5n8jB-5e4mA:
undetectable		 5n8jB-5e4mA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		3 / 3 TYR A  99
SER A 122
TRP A  35
 None
 0.70A 5n8jA-5e4mA:
undetectable		 5n8jA-5e4mA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		3 / 3 TYR A  99
SER A 122
TRP A  35
 None
 0.67A 5n8jD-5e4mA:
1.3		 5n8jD-5e4mA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5e4m HYDROXYNITRILE LYASE
(Davallia
tyermannii) 		4 / 6 ASP A  45
TRP A  47
HIS A 171
TYR A 161
 None
 1.45A 5ov9A-5e4mA:
undetectable		 5ov9A-5e4mA:
15.69