SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5e4s CONTACTIN-4
(Mus
musculus) 		5 / 11 THR A 750
VAL A 777
GLU A 774
LEU A 716
ILE A 718
 None
 1.37A 1t6zB-5e4sA:
undetectable		 1t6zB-5e4sA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5e4s CONTACTIN-4
(Mus
musculus) 		3 / 3 PRO A 703
THR A 722
PRO A 724
 None
 0.74A 2d55C-5e4sA:
undetectable		 2d55C-5e4sA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e4s CONTACTIN-4
(Mus
musculus) 		4 / 7 LEU A 752
ARG A 759
SER A 789
GLY A 708
 None
 1.12A 3hcnA-5e4sA:
undetectable		 3hcnA-5e4sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5e4s CONTACTIN-4
(Mus
musculus) 		3 / 3 PRO A 703
TYR A 735
GLY A 778
 None
 0.72A 4g2zA-5e4sA:
undetectable		 4g2zA-5e4sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5e4s CONTACTIN-4
(Mus
musculus) 		4 / 6 TYR A 670
ARG A 693
GLU A 726
PHE A 638
 None
 1.37A 4twdF-5e4sA:
undetectable
4twdG-5e4sA:
undetectable		 4twdF-5e4sA:
20.66
4twdG-5e4sA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5e4s CONTACTIN-4
(Mus
musculus) 		4 / 7 THR A 694
ALA A 613
LEU A 615
ILE A 608
 None
 0.84A 4ubsA-5e4sA:
undetectable		 4ubsA-5e4sA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5e4s CONTACTIN-4
(Mus
musculus) 		3 / 3 VAL A 717
THR A 719
ARG A 759
 None
 0.77A 5b2sB-5e4sA:
undetectable		 5b2sB-5e4sA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5e4s CONTACTIN-4
(Mus
musculus) 		3 / 3 VAL A 717
THR A 719
ARG A 759
 None
 0.76A 5b2tB-5e4sA:
undetectable		 5b2tB-5e4sA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5e4s CONTACTIN-4
(Mus
musculus) 		3 / 3 ARG A 854
LYS A 852
GLU A 837
 None
 0.78A 5d0yA-5e4sA:
undetectable		 5d0yA-5e4sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5e4s CONTACTIN-4
(Mus
musculus) 		4 / 6 ILE A 605
ALA A 659
VAL A 661
VAL A 603
 None
 0.92A 5eclD-5e4sA:
undetectable		 5eclD-5e4sA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e4s CONTACTIN-4
(Mus
musculus) 		4 / 4 GLN A 633
THR A 674
THR A 628
LEU A 651
 None
 1.48A 5m5kA-5e4sA:
undetectable		 5m5kA-5e4sA:
20.40