SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5e52 CONTACTIN-5
(Homo
sapiens) 		4 / 8 LEU A 940
TRP A 914
THR A 949
ILE A 892
 None
 0.96A 1qvtA-5e52A:
undetectable		 1qvtA-5e52A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5e52 CONTACTIN-5
(Homo
sapiens) 		3 / 3 PRO A 861
THR A 775
PRO A 777
 None
 0.85A 2d55C-5e52A:
undetectable		 2d55C-5e52A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5e52 CONTACTIN-5
(Homo
sapiens) 		5 / 11 ALA A 877
ARG A 783
VAL A 866
ILE A 868
ILE A 792
 None
 1.30A 5y80A-5e52A:
undetectable		 5y80A-5e52A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e52 CONTACTIN-5
(Homo
sapiens) 		3 / 3 GLN A 802
TRP A 741
VAL A 742
 None
 1.15A 6auuA-5e52A:
undetectable		 6auuA-5e52A:
19.53