SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  33
THR A  36
HIS A  37
TRP A 114
 None
 0.87A 1azmA-5e57A:
undetectable		 1azmA-5e57A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  33
THR A  36
HIS A  37
TRP A 114
 None
 0.83A 1bzmA-5e57A:
undetectable		 1bzmA-5e57A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.48A 1gtfA-5e57A:
undetectable
1gtfB-5e57A:
undetectable		 1gtfA-5e57A:
14.29
1gtfB-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.47A 1gtnG-5e57A:
undetectable
1gtnH-5e57A:
undetectable		 1gtnG-5e57A:
14.29
1gtnH-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  49
TYR A  59
LEU A  58
GLY A  52
 None
 1.01A 1rmtC-5e57A:
undetectable		 1rmtC-5e57A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A  24
LEU A  27
ASP A  28
 None
 0.25A 3ko0A-5e57A:
1.0		 3ko0A-5e57A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A  24
LEU A  27
ASP A  28
 None
 0.19A 3ko0T-5e57A:
1.0		 3ko0T-5e57A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 173
ALA A 118
LEU A 125
THR A  35
ILE A  47
 None
 0.91A 3prsA-5e57A:
undetectable		 3prsA-5e57A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  33
THR A  36
HIS A  37
TRP A 114
 None
 0.96A 3w6hA-5e57A:
undetectable		 3w6hA-5e57A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.49A 5eeuC-5e57A:
undetectable
5eeuD-5e57A:
undetectable		 5eeuC-5e57A:
14.29
5eeuD-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.49A 5eevC-5e57A:
undetectable
5eevD-5e57A:
undetectable		 5eevC-5e57A:
14.29
5eevD-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.50A 5eewC-5e57A:
undetectable
5eewD-5e57A:
undetectable		 5eewC-5e57A:
14.29
5eewD-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.50A 5eexC-5e57A:
undetectable
5eexD-5e57A:
undetectable		 5eexC-5e57A:
14.29
5eexD-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.50A 5eeyC-5e57A:
undetectable
5eeyD-5e57A:
undetectable		 5eeyC-5e57A:
14.29
5eeyD-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.50A 5eezC-5e57A:
undetectable
5eezD-5e57A:
undetectable		 5eezC-5e57A:
14.29
5eezD-5e57A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5e57 TRANSCRIPTION
REGULATOR AMTR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.50A 5ef0C-5e57A:
undetectable
5ef0D-5e57A:
undetectable		 5ef0C-5e57A:
14.29
5ef0D-5e57A:
14.29