SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 11 LEU A 133
ALA A 135
LEU A 152
ILE A 116
HIS A 113
 None
 1.15A 1g50A-5e59A:
undetectable		 1g50A-5e59A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 10 LEU A 133
ALA A 135
GLU A 139
ILE A 116
HIS A 113
 None
 1.31A 1pcgA-5e59A:
undetectable		 1pcgA-5e59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 10 LEU A 133
ALA A 135
LEU A 152
ILE A 116
HIS A 113
 None
 1.16A 1pcgA-5e59A:
undetectable		 1pcgA-5e59A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		4 / 5 TRP A  24
LYS A  73
LEU A  70
PRO A  23
 None
 1.40A 2dqyA-5e59A:
undetectable		 2dqyA-5e59A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 TRP A  24
LYS A  73
PRO A  23
 None
 1.29A 2dqyB-5e59A:
undetectable		 2dqyB-5e59A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		4 / 7 GLU A 130
ARG A 131
TYR A  26
ARG A  30
 None
 1.10A 2zt7A-5e59A:
undetectable		 2zt7A-5e59A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 PHE A 110
TYR A 178
LEU A  54
 None
 0.73A 3keeB-5e59A:
undetectable		 3keeB-5e59A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 PHE A 110
TYR A 178
LEU A  54
 None
 0.59A 3sueB-5e59A:
undetectable		 3sueB-5e59A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 11 PHE A 193
TYR A 200
GLY A 201
GLY A 204
ALA A 207
 None
 1.18A 3sufC-5e59A:
undetectable		 3sufC-5e59A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		4 / 8 PHE A  32
VAL A  47
TRP A  49
ILE A 188
 None
 0.92A 5hw8H-5e59A:
undetectable		 5hw8H-5e59A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		4 / 5 PRO A  78
ALA A  81
ALA A  71
ILE A  76
 None
 0.74A 5jncD-5e59A:
undetectable		 5jncD-5e59A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.37A 5ksgB-5e59A:
undetectable		 5ksgB-5e59A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.37A 5ksnA-5e59A:
undetectable		 5ksnA-5e59A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.38A 5ksnB-5e59A:
undetectable		 5ksnB-5e59A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.34A 5kt8B-5e59A:
undetectable		 5kt8B-5e59A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.37A 5sxsB-5e59A:
undetectable		 5sxsB-5e59A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.37A 5syiB-5e59A:
undetectable		 5syiB-5e59A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		4 / 5 GLU A 180
PHE A  52
ASP A  19
HIS A 113
 None
 1.28A 6b58C-5e59A:
0.3		 6b58C-5e59A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.33A 6cdqA-5e59A:
undetectable		 6cdqA-5e59A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.33A 6cdqB-5e59A:
undetectable		 6cdqB-5e59A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		5 / 9 VAL A  45
GLY A 213
SER A 216
LEU A 212
THR A 210
 None
 1.37A 6cfqB-5e59A:
undetectable		 6cfqB-5e59A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5e59 FRNE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 TRP A  17
ILE A  16
ASP A  15
 None
 0.60A 6i0y7-5e59A:
undetectable		 6i0y7-5e59A:
6.00